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Inhibition of USP14 (unknown origin) using ubiquitin rhodamine 110 as substrate in presence of Proteasome-VS at Kd at 1 to 10 uM by DUBprofiler fluorometric assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human his tagged USP14 assessed as dissociation constant by SPR analysis
Assay data:1 Tested
Inhibition of human his tagged USP14 by SPR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human USP14 using Ub-PA as substrate assessed as deubiquitination level incubated for 1 hr by SDS-PAGE assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Usp14 Inhibition Assay from US Patent US11560385: "Proteasome activity enhancing compounds"
Assay data:142 Active, 175 Activity ≤ 1 µM, 175 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
USP14 Inhibition Assay from US Patent US11242361: "Proteasome activity enhancing compounds"
Assay data:133 Active, 108 Activity ≤ 1 µM, 174 Tested
Inhibition of USP14 (unknown origin)
Assay data:13 Tested
Reversible binding affinity to USP14 in human 19S proteasome assessed as recovery of protein activity using Ubiquitin-Rhodamine 110 as substrate incubated for 20 mins
Inhibition of USP14 (unknown origin) at 10 uM relative to control
Inhibition of human His6-tagged USP14 expressed in Escherichia coli using Ubiquitin-Rhodamine110-glycine as substrate by fluorescence based analysis
Covalent binding affinity to USP14 in human U2OS cells at 20 uM using probe-1 by ABPP analysis
Inhibition of USP14 in intact human HeLa cells assessed as induction of formation of high molecular weight complexes with USP14 at 10 uM in presence of glutathione incubated for 2 hrs by immunoblot analysis
Inhibition of USP14 in human HeLa crude cell extracts assessed as induction of formation of high molecular weight complexes with USP14 at 10 uM incubated for 2 hrs in presence of glutathione by immunoblot analysis
Inhibition of USP14 in intact human HeLa cells assessed as induction of formation of high molecular weight complexes with USP14 at 10 uM in presence of dithiothreitol incubated for 2 hrs by immunoblot analysis
Inhibition of USP14 in human HeLa crude cell extracts assessed as induction of formation of high molecular weight complexes with USP14 at 10 uM incubated for 2 hrs in presence of dithiothreitol by immunoblot analysis
Inhibition of USP14 in intact human HeLa cells assessed as induction of formation of high molecular weight complexes with USP14 at 10 uM incubated for 2 hrs by immunoblot analysis
Inhibition of USP14 in human HeLa crude cell extracts assessed as induction of formation of high molecular weight complexes with USP14 at 10 uM incubated for 2 hrs by immunoblot analysis
Inhibition of full-length human USP14 using Ub-AMC substrate
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
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