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Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Cross screening panel
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP3A4 (unknown origin)
Inhibition of cullin4A neddylation in UBC/DCN1 overactivated human MGC-803 cells at 1 uM incubated for 24 hrs by Western blot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of cullin4A neddylation in UBC/DCN1 overactivated human MGC-803 cells at 0.3 to 10 uM incubated for 24 hrs by Western blot analysis
Assay data:3 Tested
Inhibition of cullin4A neddylation in human KYSE-70 cells at 0.3 to 10 uM incubated for 24 hrs by Western blot analysis
Inhibition of CYP3A4 in human liver microsomes incubated for 10 mins in presence of NADPH by LC/MS/MS analysis
Assay data:2 Tested
Time dependent inhibition of CYP3A4 in human liver microsomes assessed as residual activity at 5 uM using midazolam as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Assay data:4 Tested
Reversible inhibition of CYP3A4 in human liver microsomes assessed as residual activity at 5 uM using midazolam as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Inhibition of human CYP3A4
Assay data:2 Active, 2 Tested
Inhibition of CYP3A4 in human liver microsomes
Assay data:1 Active, 2 Tested
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC/MS/MS analysis
Induction of CYP3A4 in human hepatocytes
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate assessed as reduction in substrate hydroxylation incubated for 30 mins in presence of beta-NADPH measured by LC-MS/MS analysis
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