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Inhibitory Effect of Compounds on the Replication of Novel Coronavirus from US Patent US20240140975: "ANTIVIRAL APPLICATION OF NUCLEOSIDE ANALOG OR COMBINATION FORMULATION CONTAINING NUCLEOSIDE ANALOG"
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
Summary
Evaluation of PLK1 Kinase Activity In Vitro from US Patent US20240140962: "5,6-DIHYDROTHIENO[3,4-H]QUINAZOLINE COMPOUND"
Assay data:16 Active, 1 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
SummaryRelated BioAssays by Target
Enzymatic Inhibitory Activity (IC50) Assay from US Patent US20240132517: "MACROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
In Vitro Enzymatic Inhibitory Activity Assay from US Patent US20240132489: "AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF"
Assay data:55 Active, 55 Activity ≤ 1 µM, 55 Tested
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: Summary
Assay data:70 Active, 12 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay: Summary
Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Assay data:103 Active, 14 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay
Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested
Activity Inhibition Assay on CDK Family Kinases from US Patent US20240109898: "SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF"
Assay data:84 Active, 83 Activity ≤ 1 µM, 84 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Kinase Assay from US Patent US20240109865: "INDAZOLE COMPOUNDS AS KINASE INHIBITORS"
Assay data:359 Active, 363 Activity ≤ 1 µM, 363 Tested
CDK6/Cyclin D3 ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:67 Active, 67 Activity ≤ 1 µM, 67 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
CDK4/Cyclin D1 (Chelation-Enhance Fluorescence)(CHEF) Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:116 Active, 99 Activity ≤ 1 µM, 122 Tested
CDK4/Cyclin D1 Mobility Shift Assay (MSA) from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:55 Active, 49 Activity ≤ 1 µM, 55 Tested
CDK2/Cyclin E1 Full Length ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:111 Active, 104 Activity ≤ 1 µM, 122 Tested
CDK1/Cyclin B1 ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:83 Active, 59 Activity ≤ 1 µM, 122 Tested
Inhibition of Proteolytic Activity Asay from US Patent US20240092759: "Non-Covalent Inhibitors of the Main Protease of SARS-CoV-2 and Methods of Use"
Assay data:33 Active, 29 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Biochemical JAK Kinase Assays from US Patent US20240092758: "IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS"
Assay data:392 Active, 381 Activity ≤ 1 nM, 392 Activity ≤ 1 µM, 392 Tested
In Vitro Enzymatic Activity Assay from US Patent US20240083917: "Polycyclic Kinase Inhibitor"
Assay data:19 Active, 5 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
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