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Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Viability_24_Hours_Continuous_Exposure_U937_Cells_GTPaseCompounds
Assay data:1 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same Project
Apoptosis_24and48Hours_Continuous_Exposure_U937_Cells_GTPaseCompounds
Apoptosis_24and48Hours_Continuous_Exposure_H538_Cells_GTPaseCompounds
Viability_24_Hours_Continuous_Exposure_H538_Cells_GTPaseCompounds
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Panel of four GTPases' changes in EC50 due to different concentration of fluorescent guanine nucleotide concentration
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Comparison of test compound incubation dependence on dose response curves of small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype
Assay data:1 Active, 4 Tested
Comparison of test compound incubation dependence on dose response curves of small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
Assessing protein source dependence on dose response curves of small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
Assessing protein source dependence on dose response curves of small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype
Assay data:2 Active, 4 Tested
Actin Polymerization inhibition by compounds from Cdc42 Probe Extension Project
Assay data:2 Active, 2 Tested
Cellular toxicity assessed by Trypan Blue for compounds in active Cdc42 Probe Extension Project
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Active GTPase Screen Compounds affects on binding of VLA-4 specific ligand
Assay data:10 Active, 20 Tested
EGFR degradation assay in SCC-12F cells
Assay data:5 Active, 6 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Counter screen to determine effect of SAR compounds for Rab7 project on GST-GSH binding, round 2
Assay data:12 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Counter screen to determine effect of SAR compounds for Rab7 project on GST-GSH binding, round 1
Assay data:31 Tested
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 2
Assay data:23 Active, 19 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2
Assay data:23 Active, 20 Activity ≤ 1 µM, 25 Tested
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2
Assay data:22 Active, 21 Activity ≤ 1 µM, 25 Tested
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 2
Assay data:8 Active, 1 Activity ≤ 1 µM, 25 Tested
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