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Summary of Broad Institute MLPCN Beta Cell Apoptosis Inhibition Project
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Effects of siRNA knock down of Usp9x (a target of ML-187) on cytokine-induced apoptosis (Caspase activity) Measured in Cell-Based System Using Plate Reader
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Effects of siRNA knock down of Usp9x (a target of ML-187) on cytokine-induced beta-cell death (Cell Titer Glo) Measured in Cell-Based System Using Plate Reader
Effect of siRNA-mediated knock down of binding partners of ML-187 on cytokine-induced apoptosis cell-death
Assay data:1 Active, 7 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same Project
Binding of ML-187 to Usp9x as assessed by surface plasmon resonance Measured in Biochemical System
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
ML-187 activity in a kinase panel for Extended probe characterization for beta-cell apoptosis Measured in Biochemical System
Assay data:1 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Validation of the affinity reagent probe (ML-187) with a PEG linker: comparison of ML-187-PEG and ML-187 cell-based efficacy Measured in Cell-Based System Using Plate Reader - 2061-11_Inhibitor_Dose_DryPowder_Activity
Assay data:2 Active, 2 Tested
Effect of ML-187 on cytokines-mediated increase in STAT1 level and activation
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Quantitative proteomics to determine protein binders to ML187
Glucose-induced Insulin secretion ELISA Measured in Cell-Based System Using Plate Reader - 2061-05_Inhibitor_Dose_DryPowder_Activity
Primary beta islet insulin ELISA Measured in Cell-Based System Using Plate Reader - 2061-09_Inhibitor_Dose_DryPowder_Activity
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Primary Beta Cell Apoptosis assay Measured in Cell-Based System Using Plate Reader - 2061-07_Inhibitor_Dose_DryPowder_Activity_Set2
Apoptosis Measured in Cell-Based System Using Plate Reader - 2061-02_Inhibitor_Dose_DryPowder_Activity_Set2
Assay data:4 Active, 88 Tested
Apoptosis Measured in Cell-Based System Using Plate Reader - 2061-03_Inhibitor_Dose_DryPowder_Activity
Assay data:26 Active, 86 Tested
Detect Cellular ATP-levels in INS-1E Cells Measured in Cell-Based System Using Plate Reader - 2061-01_Inhibitor_SinglePoint_HTS_Activity
Assay data:26 Active, 19828 Tested
Nitrite Measured in Cell-Based System Using Plate Reader - 2061-04_Inhibitor_Dose_DryPowder_Activity_Set3
Assay data:27 Active, 86 Tested
Nitrite Measured in Cell-Based System Using Plate Reader - 2061-04_Inhibitor_Dose_DryPowder_Activity_Set2
Assay data:30 Active, 80 Tested
Apoptosis Measured in Cell-Based System Using Plate Reader - 2061-03_Inhibitor_Dose_DryPowder_Activity_Set2
Assay data:15 Active, 88 Tested
Nitrite Measured in Cell-Based System Using Plate Reader - 2061-04_Inhibitor_Dose_DryPowder_Activity
Assay data:7 Active, 35 Tested
ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_DryPowder_Activity
Assay data:2 Active, 88 Tested
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