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Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 30 mins by LC-MS/MS analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 mins by LC-MS/MS analysis
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 30 mins by LC-MS/MS analysis
Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate incubated for 30 mins by LC-MS/MS analysis
Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate incubated for 30 mins by LC-MS/MS analysis
Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 30 mins by LC-MS/MS analysis
Thermodynamic solubility of compound in plON buffer at 2 mg after 24 hrs
Assay data:13 Tested
SummaryPubMed Citation
Thermodynamic solubility of compound in water at 2 mg after 24 hrs
Protein binding in rat plasma at 1 uM after 4 hrs by LC-MS/MS analysis
Protein binding in human plasma at 1 uM after 4 hrs by LC-MS/MS analysis
Stability in rat plasma assessed as parent compound remaining at 1 uM up to 24 hrs by LC-MS/MS analysis
Stability in human plasma assessed as parent compound remaining at 1 uM up to 24 hrs by LC-MS/MS analysis
Stability in rat liver microsomes assessed as parent compound remaining at 1 uM up to 24 hrs by LC-MS/MS analysis
Stability in human liver microsomes assessed as parent compound remaining at 1 uM up to 24 hrs by LC-MS/MS analysis
Oral bioavailability in Sprague-Dawley rat at 5 mg/kg up to 24 hrs by LC-MS/MS analysis
Assay data:1 Tested
MRTlast in Sprague-Dawley rat at 5 mg/kg, po up to 24 hrs by LC-MS/MS analysis
Elimination rate constant Sprague-Dawley rat at 5 mg/kg, po up to 24 hrs by LC-MS/MS analysis
Tmax in Sprague-Dawley rat at 5 mg/kg, po up to 24 hrs by LC-MS/MS analysis
Half life in Sprague-Dawley rat at 5 mg/kg, po up to 24 hrs by LC-MS/MS analysis
AUClast in Sprague-Dawley rat at 5 mg/kg, po up to 24 hrs by LC-MS/MS analysis
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