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Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis
Assay data:3 Active, 3 Tested
Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 9 Tested
Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by Target
Mixed-type inhibition of recombinant C-terminal His-tagged cN2 N-terminal 30 amino acid deletion mutant (unknown origin) expressed in Escherichia coli BL21 using IMP as substrate by double reciprocal plot analysis
Assay data:1 Tested
SummaryPubMed Citation
Competitive inhibition of recombinant C-terminal His-tagged cN2 N-terminal 30 amino acid deletion mutant (unknown origin) expressed in Escherichia coli BL21 using IMP as substrate by double reciprocal plot analysis
Assay data:29 Tested
Inhibition of recombinant C-terminal His-tagged cN2 N-terminal 30 amino acid deletion mutant (unknown origin) expressed in Escherichia coli BL21 using IMP as substrate at 1 mM after 5 mins by green malachite phosphate assay
Inhibition of IRAP in HEKT cells assessed as hydrolysis of L-leucine-4-methyl-7-coumarinylamide at 100 uM after 30 mins relative to control
Assay data:9 Tested
Inhibition of IRAP in HEKT cells assessed as hydrolysis of L-leucine-4-methyl-7-coumarinylamide after 30 mins
Assay data:20 Active, 4 Activity ≤ 1 µM, 40 Tested
Apparent elimination half life in Sprague-Dawley rat at 2 mg/kg, iv by LC-MS analysis
Octanol-water partition coefficient, effective log D of the compound at pH 7.4 by chromatographic analysis
Assay data:4 Tested
Aqueous solubility of the compound at pH 6.5
Total plasma clearance in Sprague-Dawley rat at 2 mg/kg, iv by LC-MS analysis
Volume of distribution in Sprague-Dawley rat at 2 mg/kg, iv by LC-MS analysis
Drug metabolism in Sprague-Dawley rat plasma assessed as deacetylation to HFI-142 at 2 mg/kg, iv by LC-MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Drug metabolism in Sprague-Dawley rat plasma at 2 mg/kg, iv measured up to 24 hrs by LC-MS analysis
Apparent elimination half life in Sprague-Dawley rat at 10 mg/kg, ip by LC-MS analysis
Drug metabolism in Sprague-Dawley rat plasma assessed as deacetylation to HFI-142 at 10 mg/kg, po by LC-MS analysis
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