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P. falciparum growth and inhibition assays from US Patent US11903936: "Anti-malarial agents"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
DHODH Kinetic Analysis from US Patent US11903936: "Anti-malarial agents"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
DHODH Biochemical Assay from Article 10.1074/jbc.M114.558353: "In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth."
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibiton Assay from US Patent US9238653: "Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase"
Assay data:53 Active, 44 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
DHODH Inhibition Assay from Article 10.1021/jm800963t: "Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases."
Assay data:17 Active, 15 Activity ≤ 1 µM, 17 Tested
DHODH Inhibition Assay from Article 10.1021/jm801343r: "Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice."
Assay data:25 Active, 9 Activity ≤ 1 µM, 43 Tested
DHODH Inhibition Assay from Article 10.1021/jm8001026: "Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum."
Assay data:10 Active, 6 Activity ≤ 1 µM, 14 Tested
DHODH Inhibition Assay from Article 10.1016/j.bmcl.2005.09.045: "The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase."
Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested
DHODH Inhibition Assay from Article 10.1021/jm060687j: "Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase."
Assay data:8 Active, 5 Activity ≤ 1 µM, 13 Tested
Inhibition of Plasmodium falciparum DHODH expressed in Escherichia coli using L-dihydroorotate as substrate
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Plasmodium falciparum recombinant N-terminal His6-tagged DHODH (159-569 residues) expressed in Escherichia coli BL21(DE3) using DHO as substrate measured every min for 5 mins by DCPI dye-based photometric analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 17 Tested
Inhibition of Plasmodium falciparum DHODH
Inhibition of Plasmodium falciparum DHODH expressed in Escherichia coli by 2,5-dichloroindophenol-based spectrophotometric method
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Plasmodium falciparum DHODH using dihydroorotate substrate by DCIP assay
Assay data:6 Active, 3 Activity ≤ 1 µM, 54 Tested
Binding affinity to Plasmodium falciparum DHODH by isothermal titration calorimetry
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of N-terminal His6-tagged recombinant Plasmodium falciparum DHODH (amino acid residues 158 to 569) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroorotate as substrate by DCIP dye-based assay
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Inhibition of N-terminal truncated Plasmodium falciparum recombinant DHODH assessed as ubiquinone reduction to 2,6-dichloroindophenol by spectrophotometric analysis
Assay data:4 Active, 18 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of N-terminal truncated Plasmodium falciparum recombinant DHODH assessed as ubiquinone reduction to 2,6-dichloroindophenol at 10 uM by spectrophotometric analysis relative to control
Assay data:17 Tested
SummaryRelated BioAssays by Target
Inhibition of N-terminal truncated Plasmodium falciparum recombinant DHODH assessed as ubiquinone reduction to 2,6-dichloroindophenol at 100 uM by spectrophotometric analysis relative to control
Assay data:1 Tested
Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectrophotometric analysis
Assay data:13 Active, 13 Activity ≤ 1 µM, 22 Tested
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