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Inhibition of ATF6 in rat INS-1 cells assessed as suppression of tunicamycin induced GRP94 mRNA levels at 20 uM after 4 to 24 hrs by qRT-PCR method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ATF6 in rat INS-1 cells assessed as suppression of tunicamycin induced Bip mRNA levels at 20 uM after 4 to 24 hrs by qRT-PCR method
Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability by measuring media LDH content at 10 uM followed by ischemia simulation for 8 hrs and subsequent reperfusion and compound treatment for 24 hrs under normoxia condition by calcein-AM green dye based fluorescence microscopy
Assay data:2 Active, 2 Tested
Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability by measuring media LDH content at 10 uM followed by ischemia simulation for 8 hrs and subsequent reperfusion and compound treatment for 24 hrs by LDH assay
Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in catalase expression at 10 uM measured after 16 hrs by SYBR green dye-based qRT-PCR analysis
Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in GRP78 expression at 10 uM measured after 16 hrs by SYBR green dye-based qRT-PCR analysis
Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in GRP78 expression at 10 uM using compound pre-activated with hydrogen peroxide for 8 hrs prior to NRVM treatment and measured after 16 hrs by SYBR green dye-based qRT-PCR analysis
Assay data:1 Active, 2 Tested
Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in catalase expression at 10 uM using compound pre-activated with hydrogen peroxide for 8 hrs prior to NRVM treatment and measured after 16 hrs by SYBR green dye-based qRT-PCR analysis
Inhibition of tunicamycin ER stress-induced ATF6 activation in rat INS-1 cells assessed as suppression of increase in GPR94 mRNA levels up to 10 uM after 8 hrs by qRT-PCR analysis
Inhibition of tunicamycin ER stress-induced ATF6 activation in rat INS-1 cells assessed as suppression of increase in Bip mRNA levels up to 10 uM after 8 hrs by qRT-PCR analysis
qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway: Summary
Assay data:83 Active, 13 Activity ≤ 1 µM, 9315 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway
Assay data:29 Active, 6 Activity ≤ 1 nM, 218 Activity ≤ 1 µM, 9315 Tested
Determination of inhibition of thapsigargin-initiated ATF-6 protein induction in ER stress signaling.
Assay data:11 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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