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Inhibition of NOX4 ( unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of human NOX4 in T-REx-293 cells
Assay data:1 Active, 1 Tested
Inhibition of human NOX4 transfected in HEK293T cells incubated for 16 hrs ans measured after 30 mins by luminol-chemiluminescence based assay
Binding affinity to human NOX4 assessed as inhibition constant
Binding affinity to human NOX4 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence base assay
Inhibition of human NOX4 transfected in HEK293-T-REx cells assessed as PMA-induced hydrogen peroxide production pre-incubated for 10 mins and measured after 15 mins by Amplex-res based fluorescence assay
Inhibition of human NOX4 expressed in HEK293T cells assessed as inhibition of teracycline-induced hydrogen peroxide production pretreated for 18 hrs with tetracycline and treated with compound for 15 mins and measured at 10 mins post-compound treatment by Amplex Red based fluorescence analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human NOX4 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based microplate reader analysis
Assay data:23 Active, 24 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human NOX4
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Nox4 Assay from US Patent US10173988: "N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine"
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay technique
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of Nox4 in HASMCs assessed as reduction in TGFbeta-induced increase in smooth muscle alpha actin level pretreated for 30 mins followed by TGFbeta stimulation after 24 hrs by Western blot analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of NOX4 in human ARPE19 cells assessed as protection against 4-HNE-induced cell death by measuring cell viability recovery incubated for 24 hrs by MTT assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of NOX4 in human ARPE19 cells assessed as suppression of 4-HNE-induced superoxide production at 10 uM pre-incubated for 1 hr before 4-HNE addition for 1 hr by lucigenin chemiluminescence assay
Assay data:35 Tested
Inhibition of NOX4 in human ARPE19 cells assessed as protection against 4-HNE-induced cell death by measuring cell viability recovery at 10 uM incubated for 24 hrs by MTT assay
Potency index, ratio of Ki for Ewha-89403 to Ki for test compound for inhibition of human NOX4 expressed in Drosophila DUOX knockdown model
Assay data:3 Tested
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay
Assay data:10 Active, 2 Activity ≤ 1 µM, 19 Tested
Inhibition of human Nox4 expressed in COS7 cells assessed as inhibition of PMA-induced H2O2 production by amplex red dye based fluorescence assay
Assay data:18 Tested
Inhibition of full length human NOX4 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation by measuring H2O2 production by fluorescence assay in presence of superoxide dismutase
Inhibition of NOX4 in human B1647 cells assessed as reduction of ROS production after 20 mins by DCFH-DA fluorescence assay
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