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Inhibition of GIRK1/2 (unknown origin) channel
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human GIRK1/2 channel
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant human GIRK1/4 channel
Assay data:17 Active, 17 Activity ≤ 1 µM, 18 Tested
IonWorks Quattro system from US Patent US11530213: "Naphthyridinone derivatives and their use in the treatment of arrhythmia"
Assay data:93 Active, 89 Activity ≤ 1 µM, 93 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Activation of Kir3.2 channel (unknown origin) by thallium flux assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of GIRK1/4 channel (unknown origin) expressed in HEK293 cells assessed as efficacy incubated for 6 mins by thallium flux assay relative to VU0466551
Assay data:40 Tested
Activation of GIRK1/4 channel (unknown origin) expressed in HEK293 cells incubated for 6 mins by thallium flux assay
Assay data:23 Active, 12 Activity ≤ 1 µM, 42 Tested
Activation of GIRK1/2 channel (unknown origin) expressed in HEK293 cells assessed as efficacy incubated for 6 mins by thallium flux assay relative to VU0466551
Activation of GIRK1/2 channel (unknown origin) expressed in HEK293 cells incubated for 6 mins by thallium flux assay
Assay data:31 Active, 22 Activity ≤ 1 µM, 42 Tested
Displacement of [3H]glibenclamide from rat KATP at 10 uM after 60 mins by scintillation counting analysis relative to control
TBD from US Patent US10202390: "Heteroaryl substituted aminopyridine compounds"
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
Stabilization of GIRK2 channel in C57BL6 mouse brain DAergic neurons assessed as recovery of GABAB receptor stimulation-mediated firing inhibition treated with 100 uM dopamine and 10 uM sulpiride D2 antagonist under continuous perfusion followed by 300 nM baclofen treated at 300 uM measured after 15 mins by multi-electrode array (Rvb = 24.94 +-/ 14.46%)
Stabilization of GIRK2 channel in C57BL6 mouse brain DAergic neurons assessed as recovery of D2 receptor stimulation-mediated firing inhibition in presence of 100 nM quinpirole under continuous perfusion followed by treated at 300 uM measured after 15 mins by multi-electrode array (Rvb = 4.07 +-/ 3.6%)
Inhibition of human GIRK1 at 100 uM
Assay data:2 Tested
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay relative to control
Assay data:55 Tested
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay
Assay data:36 Active, 21 Activity ≤ 1 µM, 55 Tested
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay relative to control
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay
Assay data:40 Active, 32 Activity ≤ 1 µM, 56 Tested
Inhibition of Kir3.4 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Kir3.1 (unknown origin)
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