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Electrophoretic Mobility Shift Assay (MSA) from US Patent US20240109877: "PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE"
Assay data:19 Active, 19 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro BTK Kinase Assay: Btk-PolyGAT-LS Assay from US Patent US20240083900: "PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS BTK INHIBITORS"
Assay data:228 Active, 80 Activity ≤ 1 nM, 228 Activity ≤ 1 µM, 228 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TBD from US Patent US20240059694: "COMPOUND CONTAINING 1,3-BENZODIOXOL STRUCTURE AND PREPARATION METHOD AND USE THEREOF"
Assay data:30 Active, 30 Activity ≤ 1 µM, 30 Tested
BTK(h) Study from US Patent US20240051955: "4-AMINO-3-(4-PHENOXYPHENYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE DERIVATIVES AND SALTS THEREOF"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of BTK (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of N-terminal GST-tagged full length human BTK (2 to 659 residues) expressed in Sf21 insect cells using 5-FAM-EAIYAAPFAKKK as substrate at 10 uM incubated for 60 mins relative to control
Inhibition of N-terminal GST-tagged full length human BTK (2 to 659 residues) expressed in Sf21 insect cells using 5-FAM-EAIYAAPFAKKK as substrate incubated for 60 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of BTK (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of His-tagged human recombinant BTK expressed in insect cells at 200 nM by Z'-lyte assay
Inhibition of BTK (unknown origin) at 1 uM relative to control
Inhibition of BTK (unknown origin) by Z'LYTE assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Covalent inhibition of NanoLuc fused BTK (unknown origin) expressed in HEK293 cells incubated for 90 mins by NanoBRET assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of BTK phosphorylation in human JeKo-1 cells at 0.1 to 10 uM incubated for 2 hrs by Western blot analysis
Inhibition of BTK phosphorylation in human JeKo-1 cells at 0.01 to 10 uM incubated for 2 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of BTK (unknown origin) assessed as ratio of Kinact/Ki
Assay data:3 Tested
Inhibition of BTK (unknown origin) using Blk/Lyntide as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs in presence of ATP by IMAP assay
Inhibition of BTK (unknown origin) at 500 nM relative to control
Inhibition of BTK (unknown origin) by Ambit kinase assay
Assay data:4 Tested
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