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Biochemical Assay from US Patent US20240139197: "INHIBITION OF KDM5A FOR PROMOTING ANTIGEN PRESENTATION, INCREASING CD8+ T CELL INFILTRATION AND BOOSTING ANTI-TUMOR IMMUNE RESPONSE"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of KDM5B (unknown origin ) by Alphalisa analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of KDM5B (unknown origin ) by TR-FRET assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of KDM5B (unknown origin ) by HTMS analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of KDM5B (unknown origin ) by Alphascreen assay
Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested
Competitive inhibition of KDM5B (unknown origin) in human MM1.S cells by TR-FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of N-terminal his6-tagged human KDM5B (1 to 769 residues) expressed in sf9 insect cells incubated for 20 mins by Alphascreen assay
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of KDM5B in HEK293 cells by NanoBRET assay
Inhibition of KDM5B (unknown origin) by alphascreen assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant KDM5B catalytic core (1 to 729 residues) (unknown origin) expressed in baculovirus infected insect cells by FDH coupled assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of KDM5B (unknown origin)
Assay data:23 Active, 16 Activity ≤ 1 µM, 29 Tested
In Vitro Enzyme Inhibition Assay for Jarid1B Activity from US Patent US11731954: "Histone demethylase inhibitors"
Assay data:36 Active, 36 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Enzyme Inhibition Assay from US Patent US11639333: "Histone demethylase inhibitors"
Assay data:54 Active, 54 Activity ≤ 1 µM, 54 Tested
Inhibition of human KDM5B preincubated for 15 mins followed by substrate addition and measured after 20 mins using H3(1-21)K4Me3-GGK-Biotin peptide as substrate by AlphaScreen-based assay
Assay data:12 Tested
Inhibition of KDM5B (unknown origin) in presence of 300 uM 2-OG
Inhibition of KDM5B (unknown origin) in presence of 4 uM 2-OG
Binding affinity towards KDM5B (unknown origin)
Inhibition of human KDM5B using H3(1-21)K4-Me3-GGK Biotin as substrate and measured by Alphascreen assay
Inhibition of KDM5B (unknown origin) at 1 uM incubated for 30 mins by HRTF assay relative to control
Assay data:6 Tested
Inhibition of KDM5B (unknown origin) incubated for 30 mins by HRTF assay
Assay data:26 Active, 28 Activity ≤ 1 µM, 33 Tested
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