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Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Summary
Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation at 2 to 10 uM in presence of 1 to 0.2 uM quinacrine by Western blotting analysis
Assay data:1 Active, 1 Tested
Inhibition of full length mouse recombinant MoPrP (23 to 231 residues) aggregation in RML prion infected mouse ScN2a cell lysate using PrPSc as substrate by Thioflavin T based fluorometric assay
Assay data:1 Tested
Human Platelet Aggregation Inhibition Test from US Patent US10214518: "Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Activity at mouse prion protein expressed in Escherichia coli
Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by measuring PrPSc level relative to untreated control
Assay data:22 Tested
Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot
Assay data:21 Active, 21 Tested
Binding affinity to C-terminal 6x-His-tagged Syrian hamster PrPC (90 to 232 residues) by 15N-HSQC NMR spectroscopy
Binding affinity to Syrian hamster PrPC
Assay data:6 Tested
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA
Assay data:17 Active, 15 Activity ≤ 1 µM, 19 Tested
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
Assay data:208 Active, 11 Activity ≤ 1 µM, 242 Tested
Counterscreen for inhibitors of cell surface Prion Protein (PrPc): Luminescence-based cell-based high throughput assay to identify compounds that are cytotoxic to LD9 cells
Assay data:425 Active, 1465 Tested
TRFRET-based cell-based high throughput confirmation assay to identify inhibitors of cell surface Prion Protein (PRPC)
Assay data:949 Active, 1465 Tested
Inhibition of mouse PrP (23-230) fibril formation assessed as extension of lag phase at 50 uM by amyloid seeding assay (Rvb = 50 hrs)
Assay data:3 Tested
Summary of the probe development effort to identify inhibitors of cell surface Prion Protein (PRPC)
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC)
Assay data:1597 Active, 370276 Tested
Binding affinity to truncated human PrP 121-231 at 50 uM by surface plasmon resonance method
Assay data:31 Tested
Binding affinity to mouse recombinant PrP (121-231) after 10 mins by surface plasmon resonance assay
Assay data:14 Tested
Antiprion activity against mouse recombinant PrP expressed in Fukuoka-1 stain infected mouse GT1-7 cells at 10 uM after 72 hrs by Western blotting
Assay data:4 Tested
Antiprion activity against mouse recombinant PrP expressed in Fukuoka-1 stain infected mouse GT1-7 cells assessed as remaining PrP-res level at 10 uM after 72 hrs by Western blotting relative to control
Assay data:27 Tested
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