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Ebola Antiviral Assay (EBOV) from US Patent US11149049: "Substituted nucleosides, nucleotides and analogs thereof"
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of HIV/EBOV GP T519V mutant infected in 293T cells assessed as reduction in virus entry
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HIV/EBOV GP Y517S mutant infected in 293T cells assessed as reduction in virus entry
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein assessed as change in melting temperature at 500 uM by SYPRO orange dye-based fluorescence assay
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assay
Inhibition of Ebola virus Sudan envelope glycoprotein-mediated cell entry in human HuH7 cells treated with 30 mins pre-treated pseudovirus/compopund mixture and measured after 72 hrs by luciferase reporter assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain T42A mutant tagged with 6xHis/foldon trimerization sequence from the bacteriophage T4 fibritin at C terminal expressed in HEK293T cells at pH 5.2 by SYPRO orange dye-based fluorescence assay
Assay data:1 Tested
Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain H613A mutant tagged with His/foldon trimerization sequence from the bacteriophage T4 fibritin at C terminal expressed in HEK293T cells at pH 5.2 by SYPRO orange dye-based fluorescence assay
Assay data:2 Tested
Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain H613A mutant tagged with His/foldon trimerization sequence from the bacteriophage T4 fibritin at C terminal expressed in HEK293T cells assessed as decrease in melting temperature at 500 uM at pH 5.2 by SYPRO orange dye-based fluorescence assay
Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain T42A mutant tagged with 6xHis/foldon trimerization sequence from the bacteriophage T4 fibritin at C terminal expressed in HEK293T cells assessed as decrease in melting temperature at 50 uM at pH 5.2 by SYPRO orange dye-based fluorescence assay
Inhibition of Vesicular stomatitis virus particle bearing EBOV glycoprotein-mediated viral entry in African green monkey Vero cells at 40 uM incubated for 1 hr prior to viral addition measured after 1 hr by fluorescence microscopy relative to control
Assay data:3 Tested
Inhibition of Vesicular stomatitis virus particle bearing EBOV glycoprotein-mediated viral entry in African green monkey Vero cells at 75 uM incubated for 1 hr prior to viral addition measured after 1 hr by fluorescence microscopy relative to control
Inhibition of Vesicular stomatitis virus particle bearing EBOV glycoprotein-mediated viral entry in African green monkey Vero cells at 20 uM incubated for 1 hr prior to viral addition measured after 1 hr by fluorescence microscopy relative to control
Assay data:3 Active, 3 Tested
Inhibition of Vesicular stomatitis virus particle bearing EBOV glycoprotein-mediated viral entry in African green monkey Vero cells at >20 uM incubated for 1 hr prior to viral addition measured after 1 hr by fluorescence microscopy relative to control
Inhibition of Vesicular stomatitis virus particle bearing EBOV glycoprotein-mediated viral entry in African green monkey Vero cells incubated for 1 hr prior to viral addition measured after 1 hr by fluorescence microscopy relative to control
Assay data:2 Active, 2 Tested
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