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Stabilization of 14-3-3 eta (unknown origin)/ c-Raf (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of 14-3-3 eta in human Hep3B cells assessed as reduction in AKT phosphorylation at S473 residue measured after 24 hrs by western blot analysis
Inhibition of 14-3-3 eta in human Hep3B cells assessed as reduction in AKT phosphorylation at T308 residue measured after 24 hrs by western blot analysis
Inhibition of 14-3-3 eta in human Hep3B cells assessed as reduction in ERK phosphorylation measured after 24 hrs by western blot analysis
Binding affinity to 14-3-3 eta (unknown origin) assessed as dissociation constant by biolayer interferometry assay
Assay data:18 Tested
Binding affinity to 6x-His tagged 14-3-3-sigma (unknown origin) expressed in Escherichia coli BL21 (DE3) in presence of acetylated p53pT387 peptide by crystallography
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to 6x-His tagged 14-3-3-sigma (unknown origin) expressed in Escherichia coli at 1 mM by SPR assay
Assay data:1 Active, 1 Tested
Binding affinity to 6x-His tagged 14-3-3-sigma (unknown origin) expressed in Escherichia coli at 1 mM by fluorescence polarization assay
Binding affinity to 15N2H labeled and 6x-His tagged 14-3-3-sigma (unknown origin) expressed in Escherichia coli assessed as induction of broadening (intensity decrease) and chemical shift value perturbation at 2000 uM in presence of p53pT387 peptide by 1H-15N TROSY-HSQC NMR spectroscopy
Binding affinity to 15N2H labeled and 6x-His tagged 14-3-3-sigma (unknown origin) expressed in Escherichia coli assessed as induction of broadening (intensity decrease) and chemical shift value perturbation at 2000 uM in absence of of p53pT387 peptide by 1H-15N TROSY-HSQC NMR spectroscopy
Binding affinity to 6x-His tagged 14-3-3-sigma (unknown origin) expressed in Escherichia coli BL21 (DE3) at 500 uM in presence of p53pT387 peptide by WaterLOGSY NMR spectroscopy
Competitive binding affinity to 14-3-3 zeta (unknown origin) at 25 uM in presence of 1 uM synaptopodin by SPR analysis
Assay data:2 Active, 2 Tested
Binding affinity to 14-3-3 zeta (unknown origin) assessed as half life for dissociation by SPR analysis
Assay data:2 Tested
Binding affinity to 14-3-3 zeta (unknown origin) assessed as dissociation rate constant by SPR analysis
Binding affinity to 14-3-3 zeta (unknown origin) assessed as association rate constant by SPR analysis
Binding affinity to 14-3-3 zeta (unknown origin) assessed as response unit at 3.1 to 50 uM by SPR analysis
Competitive binding affinity to 14-3-3 zeta (unknown origin) at 200 uM in presence of 1 uM synaptopodin by SPR analysis
Competitive binding affinity to 14-3-3 zeta (unknown origin) at 1000 uM in presence of 25 uM synaptopodin by SPR analysis
Competitive binding affinity to 14-3-3 zeta (unknown origin) at 1000 uM in presence of 1 uM synaptopodin by SPR analysis
Binding affinity to 14-3-3 zeta (unknown origin) assessed as 14-3-3 zeta-synaptopodin interaction by fluorescence polarization assay
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