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Inhibition Assay from US Patent US8598206: "Trypsin-like serine protease inhibitors, and their preparation and use"
Assay data:9 Active, 21 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Enzymatic Assay from Article 10.1021/bi00839a042: "Nature of the active site of a subunit of the first component of human complement."
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human C1s using Z-Lyc-SBzl as substrate measured immediately by plate reader analysis
Assay data:1 Tested
Inhibition of human Complement C1s subcomponent using Val-Ser-Arg-pNA as substrate
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human C-terminal 6His-tagged complement component C1s (1 to 688 residues) expressed in mouse NS0 cells using fluorogenic Z-Lys-SBzl peptide as substrate after 5 mins by fluorescence based assay
Assay data:3 Tested
Inhibition of human plasma C1s using Cbz-Gly-Arg-S-Bzl as substrate preincubated with substrate for 15 mins followed by enzyme addition and measured after 5 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of C1s (unknown origin) using Cbz-Gly-Arg-S-Bzl as substrate preincubated with substrate for 15 mins followed by enzyme addition and measured after 5 mins
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human plasma C1s using Cbz-Gly-Arg-S-Bzl as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by DTNB reagent-based two-beam microtiter plate photometer
Inhibition of human serum C1s-mediated lysis of rabbit Ab-sensitized sheep erythrocytes after 60 mins
Inhibition of human C1s esterolytic activity using benzyloxycarbonyl-Lys-thiobenzyl as substrate
Inhibition of human serum C1s using AGLME as substrate after 30 mins
Inhibition of C1S (unknown origin) at 10 nM to 33.3 uM after 30 mins by gel-based ABPP assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of C1s (unknown origin) at 100 uM relative to control
Inhibition of C1s (unknown origin) at 100 uM
Competitive inhibition of esterase activity of human activated C1s subunit of first complement component assessed as decrease in p-nitrophenol production using N-Z-L-Lys-ONp as substrate by spectrophotometric analysis
Assay data:4 Tested
Competitive inhibition of esterase activity of human activated C1s subunit of first complement component assessed as decrease in p-nitrophenol production using N-Z-L-Tyr-ONp as substrate by spectrophotometric analysis
Assay data:20 Tested
Inhibition of CCC1s (unknown origin) using Dabcyl-SLGRKIQI-EDANS substrate assessed as residual activity at 10 uM incubated for 15 mins prior to substrate addition measured for 2 hrs
Inhibition of CCC1s (unknown origin) using Dabcyl-SLGRKIQI-EDANS substrate incubated for 15 mins prior to substrate addition measured for 2 hrs
Inhibition of human C1s
Assay data:2 Tested
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