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Inactivation of MGMT in human T98G cells assessed as reduction in protein content in cellular extract at 2 uM using O6MeG-bearing substrate (S) incubated for 2 hrs by PAGE analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Competitive inhibition of human recombinant MGMT expressed in Escherichia coli STAR BL21 pRare cells assessed as cleavage of fluorescent labelled substrate by Bsp 119I at 12.5 uM using O6MeG-bearing substrate (S) incubated for 10 mins in presence of non-substrate CT-DNA followed by substrate addition and measured after 5 mins by coupled enzymatic analysis
Assay data:3 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Competitive inhibition of human recombinant MGMT expressed in Escherichia coli STAR BL21 pRare cells assessed as cleavage of fluorescent labelled substrate by Bsp 119I at 12.5 uM using O6MeG-bearing substrate (S) incubated for 10 mins in presence of non-substrate CT-DNA followed by substrate addition and measured after 5 mins by coupled enzymatic analysis relative to control
Assay data:3 Tested
Irreversible inhibition of human recombinant MGMT expressed in Escherichia coli STAR BL21 pRare cells assessed as cleavage of fluorescent labelled substrate by Bsp 119I at 12.5 uM using O6MeG-bearing substrate (S) preincubated for 30 mins followed by substrate addition and measured after 5 mins by coupled enzymatic analysis relative to control
Assay data:8 Tested
Inhibition of human recombinant MGMT expressed in Escherichia coli STAR BL21 pRare cells assessed as cleavage of fluorescent labelled substrate by Bsp 119I at 12.5 uM using O6MeG-bearing substrate (S) incubated for 5 mins by coupled enzymatic analysis relative to control
Assay data:14 Tested
Protac activity at CRBN/MGMT in human BxPC-3 cells assessed as MGMT degradation incubated for 16 hrs by proteomic analysis
Assay data:1 Tested
Inhibition of human MGMT using 06-benzylguanine as substrate incubated for 30 mins by LC/MS analysis
Assay data:2 Active, 4 Tested
Inhibition of MGMT (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human N-terminal His-tagged MGMT (1 to 207 residues) expressed in Escherichia coli using O-6-benzylguanine as substrate after 30 mins by LC-MS analysis
Assay data:2 Active, 2 Tested
Inhibition of AGT in human SF767 cells assessed as increase in dG-dC crosslinking at 0.1 to 0.6 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to ACNU
Inhibition of AGT in human SF767 cells assessed as increase in dG-dC crosslinking at 0.1 to 0.6 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to BCNU
Inhibition of AGT in human SF763 cells assessed as increase in dG-dC crosslinking at 0.6 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to ACNU
Inhibition of AGT in human SF763 cells assessed as increase in dG-dC crosslinking at 0.4 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to ACNU
Inhibition of AGT in human SF763 cells assessed as increase in dG-dC crosslinking at 0.2 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to ACNU
Inhibition of AGT in human SF763 cells assessed as increase in dG-dC crosslinking at 0.1 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to ACNU
Inhibition of AGT in human SF763 cells assessed as increase in dG-dC crosslinking at 0.6 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to BCNU
Inhibition of AGT in human SF763 cells assessed as increase in dG-dC crosslinking at 0.4 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to BCNU
Inhibition of AGT in human SF763 cells assessed as increase in dG-dC crosslinking at 0.2 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to BCNU
Inhibition of AGT in human SF763 cells assessed as increase in dG-dC crosslinking at 0.1 mM incubated for 12 hrs by HPLC-ESI-MS/MS analysis relative to BCNU
Inhibition of AGT in human SF767 cells assessed as increase in dG-dC crosslinking incubated for 12 hrs by HPLC-ESI-MS/MS analysis
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