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Ratio of Kd in presence of 50 mM sodium phosphate buffer to Kd in presence of 1 mM sodium phosphate buffer for human GST-tagged GRB7-SH2 domain (415 to 594 residues) expressed in Escherichia coli BL21(DE3) pLys
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to GST-tagged GRB7-SH2 (415 to 532 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) in 1 mM sodium phosphate buffer by SPR analysis
Assay data:1 Tested
Binding affinity to GST-tagged GRB7-SH2 (415 to 532 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) in 50 mM sodium phosphate buffer by SPR analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of GRB7-SHC interaction in human SKBR3 cells assessed as SHC detection in cell lysates at 20 uM preincubated for 1 hr followed by fibronectin stimulation measured after 10 mins by Western blot analysis
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GRB7-HER2 interaction in human SKBR3 cells assessed as HER2 detection in cell lysates at 20 uM preincubated for 1 hr followed by fibronectin stimulation measured after 10 mins by Western blot analysis
Inhibition of GRB7-FAK interaction in human SKBR3 cells assessed as FAK detection in whole cells at 20 uM preincubated for 1 hr followed by fibronectin stimulation measured after 10 mins by Western blot analysis
Inhibition of GRB7-HER2 interaction in human SKBR3 cells assessed as HER2 detection in whole cells at 20 uM preincubated for 1 hr followed by fibronectin stimulation measured after 10 mins by Western blot analysis
Inhibition of GRB7-SHC interaction in human SKBR3 whole cells at 20 uM preincubated for 1 hr followed by fibronectin stimulation measured after 10 mins by Western blot analysis
Ratio of Kd in presence of 1 mM sodium phosphate buffer to Kd in presence of 50 mM sodium phosphate buffer for human GST-tagged GRB7-SH2 domain (415 to 594 residues) expressed in Escherichia coli BL21(DE3) pLys
Assay data:3 Tested
Ratio of Kd in presence of 1 mM sodium phosphate buffer to Kd in presence of 50 mM sodium phosphate buffer for GST-tagged GRB7-SH2 (415 to 532 residues) (unknown origin) expressed in Escherichia coli BL21(DE3)
Binding affinity to human GST-tagged GRB7-SH2 domain (415 to 594 residues) expressed in Escherichia coli BL21(DE3) pLys after 60 to 80 secs in presence of 1 mM phosphate buffer by SPR assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Binding affinity to human GST-tagged GRB7-SH2 domain (415 to 594 residues) expressed in Escherichia coli BL21(DE3) pLys after 60 to 80 secs in presence of 50 mM phosphate buffer by SPR assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of GRB7-FAK interaction in human SKBR3 cells assessed as FAK detection in cell lysates at 20 uM preincubated for 1 hr followed by fibronectin stimulation measured after 10 mins by Western blot analysis
Binding affinity to Grb7-SH2 domain (unknown origin) using 100 mM phosphate buffer by SPR analysis
Assay data:1 Active, 1 Tested
Binding affinity to Grb7-SH2 domain (unknown origin) without using phosphate buffer by SPR analysis
Binding affinity to GST-tagged Grb7-SH2 domain (415 to 532 amino acid residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using 20 mM Tris/1 mM NaPO4 buffer by SPR analysis
Assay data:2 Active, 3 Tested
Binding affinity to GST-tagged Grb7-SH2 domain (415 to 532 amino acid residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using 350 mM NaPO4 buffer by SPR analysis
Assay data:1 Active, 3 Tested
Binding affinity to GST-tagged Grb7-SH2 domain (415 to 532 amino acid residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using 50 mM NaPO4 buffer by SPR analysis
Binding affinity to GST-tagged Grb7-SH2 domain (415 to 532 amino acid residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using 20 mM Tris buffer by SPR analysis
Binding affinity to human GRB7 SH2-NSC642056 domain expressed in Escherichia coli BL21 (DE3) assessed as melting temperature at 100 uM by thermofluor based melting point shift assay
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