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High-Throughput Assay from US Patent US11591319: "Small molecule inducers of autophagy"
Assay data:31 Active, 10 Activity ≤ 1 µM, 51 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Potency index, ratio of Tat-SP4 Kd to test compound Kd for binding affinity to Beclin 1 coiled coil domain (unknown origin) by isothermal titration calorimetry assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of FLAG-tagged Beclin 1 self-association in HEK293T cells cotransfected with GFP assessed as reduction in beclin 1- GFP pull down by FLAG-beclin 1 by coimmunoprecipitation assay
Assay data:1 Tested
Binding affinity to Beclin 1 coiled coil domain (unknown origin) by isothermal titration calorimetry assay
Assay data:13 Active, 5 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to BECN1 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to BECN1 in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay
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