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Inhibition of cystine/glutamate antiporter system xc- in human Calu1 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ free uptake buffer by scintillation counting assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ free uptake buffer by scintillation counting assay
Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptake
Assay data:1 Active, 1 Activity ≤ 1 µM, 5 Tested
Human Cystine/glutamate transporter (SLC7 family)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometry
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Inhibition of system xc-transporter-mediated [3H]-L-glutamate uptake in human SNB19 cells at 500 uM after 5 mins by liquid scintillation counting analysis relative to control
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of cystine/glutamate transporter in human SNB19 cells assessed as [3H]glutamate uptake at 500 uM
Assay data:23 Tested
Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid scintillation counting
Assay data:17 Tested
Inhibition of amino acid transport system xc-
Assay data:2 Active, 4 Tested
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake at 500 uM after 24 hrs by liquid scintillation counting
Assay data:18 Tested
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as attenuation of exchange of extracellular L-cystine with intracellular L-glutamate at 500 uM by fluorometric assay
Activity at amino acid transport system xc- in human SNB19 cells assessed as induction of L-glutamate efflux at 500 uM by fluorometric assay
Assay data:7 Tested
Competitive inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by Michaelis-Menten plot analysis
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation counting
Assay data:5 Tested
Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation counting
Inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells at 500 uM by liquid scintillation counting
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake at 500 uM by liquid scintillation counting
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake at 250 uM by liquid scintillation counting
Assay data:16 Tested
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