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BMP2K SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to recombinant BMP2K (unknown origin) assessed as dissociation constant by DSF assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant BMP2K (unknown origin) at 10 uM by DSF assay relative to staurosporine
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant BMP2K (unknown origin) assessed as change in melting temperature at 10 uM by DSF assay
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000717a BMP2K
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a BMP2K
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000698a BMP2K
Affinity Biochemical interaction (Competition binding assay) EUB0000166b BMP2K
Affinity Biochemical interaction (TR-FRET binding-displacement assays) EUB0000165b BMP2K
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000165b BMP2K
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: S38-E345
Assay data:27 Tested
Binding affinity to BIKE (unknown origin) assessed as change in melting temperature at 10 uM by SYPRO orange dye based DSF assay
Inhibition of BIKE (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo as substrate incubated for 2 hrs by NanoBRET assay
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of BIKE (unknown origin)
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
Binding affinity to BIKE (unknown origin)
Inhibition of human wild type partial length BIKE (S34 to N329 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM relative to control
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