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Protac activity at CRBN/CIAPIN1 in human BxPC-3 cells assessed as CIAPIN1 degradation incubated for 16 hrs by proteomic analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CIAPIN1 in human KMS11 cells assessed as deletion of depletion of stable CIAPIN1 levels at 1 to 10 uM incubated for 6 hrs by immunoblot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CIAPIN1 in human KMS11 cells assessed as induction of high molecular weight complex formation at 1 to 10 uM incubated for 6 hrs by immunoblot analysis
Inhibition of CIAPIN1 in human KMS11 cells assessed as deletion of depletion of stable CIAPIN1 levels at 100 nM incubated for 6 hrs by immunoblot analysis
Inhibition of CIAPIN1 in human KMS11 cells assessed as induction of high molecular weight complex formation at 100 nM incubated for 6 hrs by immunoblot analysis
Inhibition of CIAPIN1 in human KMS11 cells assessed as induction of protein aggregation at 100 nM incubated for 1 hr by immunoblot analysis
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as disruption of intra-chain disulfide bond in unmodified peptide containing Cys249
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as covalent modification of cysteine residues incubated for 2 hrs LC-MS/MS analysis
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as covalent adduct formation at 10 molar equivalents incubated for 2 hrs by electrospray MS analysis
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as increase in high molecular weight CIAPIN1 complexes at 1 to 10 molar equivalent 1 by SDS-PAGE and Coomassie Blue staining based method
Inhibition of CIAPIN1 in human KMS11 crude cell extracts assessed as induction of formation of high molecular weight complexes with CIAPIN1 at 20 uM incubated for 2 hrs in presence of GSH by immunoblot analysis
Inhibition of CIAPIN1 in human KMS11 crude cell extracts assessed as induction of formation of high molecular weight complexes with CIAPIN1 at 20 uM incubated for 2 hrs by immunoblot analysis
Covalent binding affinity to CIAPIN1 in human U2OS cells at 20 uM using probe-1 by ABPP analysis
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as accumulation of protein aggregates at 0.1 to 1.6 uM incubated for 1 to 6 hrs by size exclusion chromatography
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