Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
IC50 Determination from US Patent US20240043470: "MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS"
Assay data:80 Active, 18 Activity ≤ 1 µM, 160 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human 20S immuno proteosome beta5i subunit using Suc-LLVY-AMC as substrate measured after 10 mins by fluorescence based analysis
Assay data:2 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Competitive inhibition of human 20S constitutive proteosome beta5c subunit using Suc-LLVY-AMC as substrate measured after 10 mins by fluorescence based analysis
Assay data:4 Active, 4 Tested
Inhibition of human 20S constitutive proteosome beta5c subunit using Suc-LLVY-AMC as substrate measured after 10 mins by fluorescence based analysis
Assay data:2 Active, 9 Tested
Protac activity at CRBN/Rpn13 in human MM1.S cells measured after 16 hrs by immunoblotting analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human 20S proteasome
Assay data:1 Active, 2 Tested
Inhibition of beta5 proteasome (unknown origin)
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of beta2 proteasome (unknown origin)
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of 20S proteasome (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of beta 1 proteasome (unknown origin)
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Proteasome Inhibitory Activity from US Patent US11542283: "Synthesis of peptide borate ester compound and use thereof"
Activation of human 20S proteosome at chymotrypsin like site assessed as maximum fold change in substrate degradation using Suc-LLVY-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis relative to control
Assay data:7 Tested
Activation of human 20S proteosome at chymotrypsin like site assessed as substrate degradation using Suc-LLVY-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis
Assay data:7 Active, 1 Activity ≤ 1 µM, 17 Tested
Activation of human 20S proteosome at trypsin-like site assessed as maximum fold change in substrate degradation using Boc-LLR-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis relative to control
Assay data:8 Tested
Activation of human 20S proteosome at trypsin-like site assessed as substrate degradation using Boc-LLR-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis
Activation of human 20S proteosome at caspase-like site assessed as maximum fold change in substrate degradation using Z-LLE-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis relative to control
Assay data:6 Tested
Activation of human 20S proteosome at caspase-like site assessed as substrate degradation using Z-LLE-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis
Assay data:6 Active, 17 Tested
Activation of human 20S proteosome assessed as maximum fold change in substrate degradation using Suc-LLVY-AMC/Z-LLE-AMC/Boc-LLR-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis relative to control
Assay data:9 Tested
Activation of human 20S proteosome assessed as substrate degradation using Suc-LLVY-AMC/Z-LLE-AMC/Boc-LLR-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis
Inhibition of 20S proteasome subunit beta-2c (unknown origin) using Ac-KQL-AMC as substrate and measured after 30 mins
Assay data:3 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on