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Potency index, ratio of m7GMP Kd to test compound Kd for inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of P32-[alpha-GTP] cap radiolabelled RNA binding to recombinant eIF4E (unknown origin) assessed as decrease in cross linked RNA-eIF4E complex formation at 10 uM preincubated with UV radiation for 30 mins followed by RNase addition and measured after 30 mins by SDS-PAGE based autoradiographic analysis relative to control
Inhibition of m7 GDP fluorescent probe binding to recombinant eIF4E (unknown origin) at 10 uM by fluorescence polarization assay relative to control
Inhibition of P32-[alpha-GTP] cap radiolabelled RNA binding to recombinant eIF4E (unknown origin) assessed as decrease in cross linked RNA-eIF4E complex formation preincubated with UV radiation for 30 mins followed by RNase addition and measured after 30 mins by SDS-PAGE based autoradiographic analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of P32-[alpha-GTP] cap radiolabelled RNA binding to recombinant eIF4E (unknown origin) assessed as decrease in cross linked RNA-eIF4E complex formation at 100 uM preincubated with UV radiation for 30 mins followed by RNase addition and measured after 30 mins by SDS-PAGE based autoradiographic analysis relative to control
Assay data:22 Tested
Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization assay
Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) at 100 uM by fluorescence polarization assay relative to control
Binding affinity to EIF4E (unknown origin) by fluorescence polarization assay
Inhibition of eIF4E phosphorylation in human MDA-MB-231 cells at 5 uM and measured upto 96 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of eIF4E phosphorylation in human A549 cells at 5 uM and measured upto 96 hrs by Western blot analysis
Human eIF4E/4G2 Binding Assay from US Patent US11753403: "EIF4E inhibitors and uses thereof"
Assay data:241 Active, 104 Activity ≤ 1 µM, 295 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of eIF4E phosphorylation in human MDA-MB-231 cells at 5 to 20 uM pretreated for 3 hrs followed by UV irradiation and recovery for 40 mins with compound by Western blot analysis
Inhibition of phosphorylation of eIF4E (unknown origin)
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Inhibition of eIF4E (unknown origin) at 1 uM
Inhibition of eIF4E (unknown origin)
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of eIF4E phosphorylation in human MV4-11 cells
Inhibition of eIF4E phosphorylation in human U-937 cells
Inhibition of Ser 209 phosphorylation of eIF4E (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cells
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of eIF4E phosphorylation in HEK293 cells incubated for 60 mins by Western blot assay
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