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Inhibition of N-terminal 6His-MBP-tagged recombinant human IP6K1 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation at 10 nM measured after 180 mins by HPLC analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant full length human IP6K1 assessed as inorganic phosphate release measured after 30 mins by ADP-Glo Max assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of N-terminal 6His-MBP-tagged recombinant human IP6K1 expressed in Escherichia coli assessed as inorganic phosphate release using InsP6 as substrate in presence of ATP measured after 60 to 120 mins by malachite green based colorimetric - DIPP1 coupled enzyme assay
Assay data:35 Active, 27 Activity ≤ 1 µM, 37 Tested
Inhibition of N-terminal 6His-MBP-tagged recombinant human IP6K1 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation measured after 180 mins by HPLC analysis
Inhibition of recombinant full length human IP6K1 in HCT-116 cells assessed as reduction in InsP7 level at 10 to 30 uM measured after 30 mins by toluidine blue staining based analysis
Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (IP6K1)
Assay data:160 Active, 10 Activity ≤ 1 µM, 1223 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (IP6K1)
Assay data:1159 Active, 143951 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of IP6K1 (unknown origin) incubated for 30 mins using IP6 as substrate in presence of ATP by ADP-Glo reagent based luminescence assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 29 Tested
Binding affinity to IP6K1 (unknown origin) assessed as change in melting temperature at 1.11 uM by SYPRO orange dye based assay
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to IP6K1 (unknown origin) assessed as change in melting temperature by SYPRO orange dye-based assay
Inhibition of IP6K1 (unknown origin) in presence of ATP at Km concentration by Cheng-Prusoff equation analysis
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