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Inhibition of human TASK-3 expressed in Xenopus laevis oocytes assessed as inhibition of channel current at 10 uM at +40mV holding potential by two-electrode voltage clamp assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human TASK-3 expressed in Xenopus laevis oocytes assessed as inhibition of channel current at +40mV holding potential by two-electrode voltage clamp assay
Assay data:2 Active, 2 Tested
Inhibition of Recombinant TASK-1 and TASK-3 In Vitro from US Patent US11208422: "Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors"
Assay data:53 Active, 53 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Recombinant TASK-1 and TASK-3 In Vitro from US Patent US11098063: "Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders"
Assay data:113 Active, 111 Activity ≤ 1 µM, 113 Tested
Inhibition In Vito Assay from US Patent US10759794: "2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders"
Assay data:75 Active, 64 Activity ≤ 1 µM, 77 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Electrophysiological Assay from US Patent US10414765: "Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same"
Assay data:48 Active, 34 Activity ≤ 1 µM, 48 Tested
Selectivity screen (KCNK9)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activation of K2P9.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 150 uM at -80 mV holding potential by two-electrode voltage clamp assay relative to control
Activation of K2P9.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential at 100 uM by two-electrode voltage clamp assay relative to control
Activation of K2P9.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 150 uM at -80 mV holding potential by two-electrode voltage clamp assay
Activation of K2P9.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 100 uM at -80 mV holding potential by two-electrode voltage clamp assay
Activation of recombinant human TASK3 expressed in HEK293T cells assessed as increase in K+ current amplitude at 10 uM by whole cell voltage clamp electrophysiological analysis
Assay data:1 Active, 1 Tested
Inhibition of rat TASK3 expressed in African green monkey COS7 cells by outside-out patches based electrophysiology assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human TASK3 expressed in HEK293 cells by Qpatch HT platform based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of human TASK3 expressed in human tsA201 cells at 1 uM by whole cell patch clamp assay relative to control
Inhibition of human TASK3 expressed in Xenopus oocytes at 1 uM by whole cell patch clamp assay relative to control
Inhibition of human TASK3 expressed in CHOK1 cells by Ti+ flux assay
Inhibition of human TASK3 expressed in CHO cells by Qpatch HT platform based assay
Inhibition of human TASK3 expressed in HEK293 by whole cell voltage clamp assay
Inhibition of rat TASK3 expressed in African green monkey COS7 cells at 1 mM by outside-out patches based electrophysiology assay relative to control
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