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Activation of LXR beta in human HepG2 cells at 10 uM incubated for 24 hrs by luciferase reporter assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of LXR alpha in human HepG2 cells at 10 uM incubated for 24 hrs by luciferase reporter assay
Binding affinity to full length human LXRalpha assessed as dissociation constant by SPR analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at LXRalpha in human HepG2 cells assessed as upregulation of CYP7A1 protein expression level at 25 uM incubated for 24 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at LXRalpha in human HepG2 cells assessed as upregulation of CYP7A1 mRNA expression by measuring fold change at 25 uM incubated for 24 hrs by RT-qPCR analysis
Assay data:2 Tested
Agonist activity at LXRalpha in human HepG2 cells assessed as upregulation of ABCA1 mRNA expression by measuring fold change at 25 uM incubated for 24 hrs by RT-qPCR analysis
Agonist activity at LXRalpha in human HepG2 cells assessed as upregulation of ABCA1 protein expression level at 25 uM incubated for 24 hrs by Western blot analysis
Antagonist activity at NR1H3 (unknown origin) at 1 uM
Antagonist activity at NR1H2 (unknown origin) at 1 uM
Inverse agonist activity at NR1H3 (unknown origin) at 1 uM
Inverse agonist activity at NR1H2 (unknown origin) at 1 uM
Agonist activity at NR1H3 (unknown origin) at 1 uM
Agonist activity at NR1H2 (unknown origin) at 1 uM
Agonist activity at LXR in human HepG2 cells assessed as reduction in HMGCR mRNA expression upto 10 uM measured after 72 hrs by RT-qPCR analysis
Assay data:1 Active, 1 Tested
Agonist activity at LXR in human HepG2 cells assessed as reduction in SREBP1c proteolytic processing upto 10 uM measured after 72 hrs by Western blot analysis
Agonist activity at LXR in human HepG2 cells assessed as reduction in HMGCR mRNA expression measured after 72 hrs by RT-qPCR analysis
Agonist activity at LXR in human HepG2 cells assessed as reduction in SREBP1c proteolytic processing measured after 72 hrs by Western blot analysis
Agonist activity at LXR in human HepG2 cells assessed as increase of IDOL mRNA expression level at 10 uM by RT-qPCR analysis
Agonist activity at LXR in cholesterol treated human THP-1 cells assessed as stimulation of plasma mediated cholesterol efflux at 5 uM pre incubated for 24 hrs followed by plasma addition measured after 6 hrs by liquid scintillation counting analysis
Agonist activity at LXR in human THP-1 cells assessed as increase of ABCA1 mRNA expression level at 1 to 10 uM by RT-qPCR analysis
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