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Inhibition of Cyb5R3 (unknown origin) expressed in HEK293 cells at 30.16 uM incubated for 24 hrs in presence of potassium ferricyanide and NADH by spectrophotometric assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of Cyb5R3 (unknown origin) expressed in HEK293 cells at 36.82 uM incubated for 24 hrs in presence of potassium ferricyanide and NADH by spectrophotometric assay
Inhibition of Cyb5R3 (unknown origin) expressed in HEK293 cells at 21.86 uM incubated for 24 hrs in presence of potassium ferricyanide and NADH by spectrophotometric assay
Inhibition of N-terminal His6-tagged human Cyb5R3 expressed in Escherichia coli SoluBL21 assessed as reduction in NADH-ferricyanide reductase activity pre-incubated for 15 mins before addition of NADH and potassium ferricyanide by spectrophotometric assay
Assay data:4 Tested
Inhibition of N-terminal His6-tagged human Cyb5R3 expressed in Escherichia coli SoluBL21 assessed as reduction in NADH-ferricyanide reductase activity at 50 uM pre-incubated for 15 mins before addition of NADH and potassium ferricyanide by spectrophotometric assay relative to control
Assay data:1 Active, 8 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of N-terminal His6-tagged human Cyb5R3 expressed in Escherichia coli SoluBL21 assessed as reduction in NADH-ferricyanide reductase activity at 500 uM pre-incubated for 15 mins before addition of NADH and potassium ferricyanide by spectrophotometric assay relative to control
Assay data:6 Active, 17 Tested
Inhibition of Cyb5R3 in rat thoracodorsal arteries assessed as inhibition of DETA NONOate-induced response incubated for 24 hrs in presence of sGC activator Bay 58-2667 by pressure myography
Inhibition of Cyb5R3 in rat thoracodorsal arteries assessed as inhibition of DETA NONOate-induced response incubated for 24 hrs by pressure myography
Assay data:1 Active, 1 Tested
Inhibition of Cyb5R3 in DETA NONOate-stimulated rat aortic VSMs assessed as reduction in NO-induced cGMP production in presence of sGC activator Bay 58-2667
Inhibition of Cyb5R3 in DETA NONOate-stimulated rat aortic VSMs assessed as reduction in NO-induced cGMP production relative to control
Inhibition of Cyb5R3 in rat aortic VSMs assessed as reduction in decrease in basal cGMP levels
Inhibition of Cyb5R3 in rat aortic VSMs assessed as reduction in decrease in sGC protein by Western blot analysis
In vitro effect on methemoglobin reductase activity at specified 33 uM concentration; enzyme activity expressed as nmoles of methemoglobin reduced min-1.mg. protein -1
Assay data:10 Tested
In vitro effect on methemoglobin reductase activity at specified 166 uM concentration; enzyme activity expressed as nmoles of methemoglobin reduced min-1.mg. protein -1
In vitro effect on methemoglobin reductase activity at 33 uM concentration; enzyme activity expressed as nmoles of methemoglobin reduced min-1.mg. protein -1
Assay data:5 Tested
In vitro effect on methemoglobin reductase activity at 166 uM concentration; enzyme activity expressed as nmoles of methemoglobin reduced min-1.mg. protein -1
Percentage inhibition of methemoglobin reductase by the compound at 133 uM concentration
In vitro activity against methemoglobin reductase at 166 uM concentration in blood from a normal Beagle dog
SummaryPubMed CitationRelated BioAssays by Target
In vitro activity against methemoglobin reductase at 166 uM concentration in blood from a normal Beagle dog P<0.01
In vitro activity against methemoglobin reductase at 166 uM concentration in blood from a normal Beagle dog P<0.005
Assay data:2 Tested
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