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Lipoxygenase 15-LO Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of 15-LOX (unknown origin)
Assay data:23 Active, 1 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LOX (unknown origin) at 1 uM
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of LOX15 (unknown origin)
Assay data:1 Active, 2 Tested
Lipoxygenase-15 Assay (LO-15-Assay) from US Patent US20230303506: "COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA"
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
LOX Enzyme Activity Assay from US Patent US11608330: "Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer"
Assay data:86 Active, 28 Activity ≤ 1 µM, 89 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Lipoxygenase-15 Assay from US Patent US11584728: "Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia"
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
Effect on human wild type ALOX15-mediated product pattern assessed as reduction in (15S-H(p)ETE) oxygenation product using arachidonic acid as substrate by 4 uM by RP-HPLC analysis
Assay data:2 Active, 2 Tested
Effect on rabbit wild type ALOX15-mediated product pattern assessed as change in product specificity using linoleic acid as substrate by 4 uM by RP-HPLC analysis
Reversible inhibition of rabbit ALOX15 assessed as recovery of catalytic activity by spectrophotometry
Mixed mode inhibition of wild type Rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli assessed as inhibition constant using linoleic acid as substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity ratio of IC50 for Inhibition of recombinant human N-terminal His-tagged ALOX15 expressed in Escherichia coli Rosetta2(DE3)pLysS using linoleic acid as substrate to IC50 for Inhibition of recombinant human N-terminal His-tagged ALOX15 expressed in Escherichia coli Rosetta2(DE3)pLysS using arachidonic acid as substrate by HPLC based assay
SummaryPubMed CitationRelated BioAssays by Target
Selectivity ratio of IC50 for Inhibition of wild type rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli using linoleic acid as substrate to IC50 for Inhibition of wild type rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli using arachidonic acid as substrate by HPLC based assay
Mixed mode inhibition of wild type Rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli assessed as inhibition constant using arachidonic acid as substrate
Inhibition of wild type Rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli assessed as effect on Km using arachidonic acid as substrate
Inhibition of wild type rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli assessed as decrease in Kcat using arachidonic acid as substrate
Non-competitive inhibition of wild type rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli assessed as inhibition constant using linoleic acid as substrate
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of wild type rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli assessed as effect on Km using linoleic acid as substrate
Inhibition of wild type rabbit N-terminal His-tagged ALOX15 expressed in Escherichia coli assessed as decrease in Kcat using linoleic acid as substrate
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