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Inhibition of GP130 in human A549 cells assessed as reduction in survivin protein expression after 24 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GP130 in human A549 cells assessed as reduction in cyclin-D1 protein expression after 24 hrs by Western blot analysis
Inhibition of GP130 in human A549 cells assessed as reduction in bcl2 protein expression after 24 hrs by Western blot analysis
Inhibition of GP130 in human A549 cells assessed as reduction in STAT3 dimer DNA binding activity in nuclear extract in presence of hSIE probe at 3 to 9 uM after 24 hrs by EMSA analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GP130 in human A549 cells assessed as decrease in IL6-induced STAT3 phosphorylation at Y705 residue at 9 uM incubated for 24 hrs by western blot analysis
Inhibition of GP130 in human A549 cells assessed as decrease in JAK2 phosphorylation at 3 to 9 uM incubated for 24 hrs by western blot analysis
Inhibition of GP130 in human A549 cells assessed as decrease in STAT3 phosphorylation at Y705 residue at 3 to 9 uM incubated for 24 hrs by western blot analysis
Binding affinity to D2/D3 domain of FLAG-tagged GP130 (unknown origin) expressed in HEK293 cells assessed as inhibition of rhIL6/Myc-tagged IL6R interaction with GP130 at 10 uM preincubated for 4 hrs followed by stimulation with recombinant human IL6 for 30 mins by co-immunoprecipitation method
Binding affinity to GP130 in human A549 cell lysates assessed as decrease in pronase mediated protein degradation by measuring increase in abundance of GP130 band at 100 to 1000 uM preincubated for 1 hr followed by pronase addition for 30 mins by DARTS assay
Binding affinity to immobilized GP130 (unknown origin) by SPR analysis
Assay data:1 Active, 2 Tested
Binding affinity to immobilized GP130 (unknown origin) assessed as response unit at 20 uM by SPR analysis
Assay data:27 Tested
Inhibition of IL-6-induced gp130 phosphorylation in human U266 cells at 10 and 20 uM pre-incubated for 1 hr before IL-6 stimulation for 10 to 15 mins by Western blot analysis
Binding affinity to wild-type gp130 (unknown origin) at 0.19 to 200 uM by surface plasmon resonance analysis
Inhibition of gp130-IL6/IL-Ralpha interaction in human HepG2 cells assessed as inhibition of IL-6-induced STAT3 activation by luciferase reporter gene assay
Assay data:6 Active, 15 Tested
Inhibition of IL-6Ralpha/GP130 interaction in human PANC-1 cells assessed as inhibition of IL-6-induced STAT3 phosphorylation at Y705 at 25 uM preincubated for 30 mins followed by IL-6 induction measured after 24 hrs by Western blot analysis
Binding affinity to GP130 in human RH30 cells assessed as protection against pronase-induced cleavage at 100 to 1000 uM preincubated for 1 hr followed by pronase induction measured after 30 mins by DARTS assay
Assay data:2 Active, 2 Tested
Inhibition of IL-6Ralpha/GP130 interaction in ER-negative human SUM159 cells overexpressing IL-6 assessed as inhibition of constitutive STAT3 phosphorylation at Y705 at 15 to 50 uM after 24 hrs by Western blot analysis
Inhibition of IL-6Ralpha/GP130 interaction in human PANC-1 cells assessed as inhibition of IL-6-induced STAT3 phosphorylation at Y705 preincubated for 30 mins followed by IL-6 induction measured after 24 hrs by Western blot analysis
Inhibition of LIFR/GP130 interaction in human PANC-1 cells assessed as inhibition of LIF-induced STAT3 phosphorylation at Y705 at 25 uM after 24 hrs by Western blot analysis
Assay data:2 Tested
Inhibition of IL-6Ralpha/GP130 interaction in ER-negative human SUM159 cells overexpressing IL-6 assessed as inhibition of constitutive STAT3 phosphorylation at Y705 at 10 to 30 uM after 24 hrs by Western blot analysis
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