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Inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled 55Fe2+ uptake at 10 uM preincubated with compound for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ for 15 mins at extracellular pH of 5.5 by scintillation counting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human DMT1 expressed in Xenopus laevis oocytes assessed as reduction in radiolabeled 55Fe2+ uptake at 10 uM preincubated for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ and measured after 10 mins by scintillation counting method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human DMT1 expressed in HEK293T cells assessed as inhibition of radiolabeled 55Fe2+ uptake preincubated with compound for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ for 15 mins at extracellular pH of 5.5 by scintillation counting analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human DMT1 expressed in HEK293 cells assessed as inhibition of radiolabeled 55Fe2+ uptake incubated for 1 hr by microplate scintillation counting analysis
Assay data:1 Active, 2 Tested
Inhibition of human DMT1 expressed in Xenopus oocytes assessed as inhibition of channel currents at -50 mV holding potential by two-electrode voltage clamp assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake in presence of saturating iron concentration by Dixon plot analysis
Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake by Dixon plot analysis
Human DMT1 (SLC11 family of proton-coupled metal ion transporters)
Inhibition of NRAMP1 expressed in CHO cells
Assay data:48 Tested
Inhibition of human DMT1 at 10 uM after 20 mins by calcein quenching fluorescence assay relative to desferoxamine
Assay data:10 Tested
Inhibition of human DMT1 expressed in CHO cells assessed as effect on ionic current at 10 uM by whole-cell voltage clamp assay
Assay data:2 Tested
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method
Assay data:39 Active, 30 Activity ≤ 1 µM, 48 Tested
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