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Protac activity at CRBN/STAT2 in human SUP-M2 cells assessed as STAT6 degradation at 0.25 to 100 uM incubated for 4 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Protac activity at CRBN/STAT2 in human SU-DHL-1 cells assessed as STAT6 degradation at 0.25 to 100 uM incubated for 4 hrs by Western blot analysis
Protac activity at CRBN/STAT2 in human MOLM16 cells assessed as STAT2 degradation at 0.25 to 100 uM incubated for 4 hrs by Western blot analysis
Induction of STAT2 degradation in human SUP-M2 cells at 0.25 to 100 uM incubated for 14 hrs by Western blot analysis
Assay data:3 Tested
Binding affinity to human recombinant STAT2 assessed as dissociation constant incubated for 15 mins by biolayer interferometry
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of STAT2 degradation in human SU-DHL-1 cells at 0.25 to 100 uM incubated for 14 hrs by Western blot analysis
Induction of STAT2 degradation in human MOLM16 cells at 0.25 to 100 uM incubated for 4 hrs by Western blot analysis
Protac activity at CRBN/STAT2 in human BxPC-3 cells assessed as STAT2 degradation incubated for 16 hrs by proteomic analysis
Effect on STAT2 at Y689 phosphorylation level in human NCI-H1975 incubated for 12 hrs by human phosphokinase proteome profiler array relative to beta-catenin
Assay data:2 Tested
Effect on STAT2 at Y689 phosphorylation level in human NCI-H1975 incubated for 12 hrs by human phosphokinase proteome profiler array relative to control
Protac activity at CRBN/STAT2 in human SUDHL1 cells assessed as degradation of STAT2 at 10 uM incubated for 18 hrs by Western blot analysis
Protac activity at CRBN/STAT2 in human SUDHL1 cells assessed as degradation of STAT2 at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis
Protac activity at CRBN/STAT2 in human MOLM16 cells assessed as degradation of STAT2 at 10 uM incubated for 4 hrs by Western blot analysis
Protac activity at CRBN/STAT2 in human MOLM16 cells assessed as degradation of STAT2 at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis
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