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Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b RIOK3
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000698a RIOK3
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Ambit kinase binding assay panel) EUB0000609a RIOK3
Binding affinity to RIOK3 in human MKN-1 cells assessed as negative shift in melting temperature at 5 uM incubated for 3 hrs followed by heat treatment at 52 to 62 degC for 3 mins by CETSA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to wild-type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by KINOMEscan assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
RIOK3 DiscoveRx kinase panel
Inhibition of wild type full length human RIOK3 (M1 to E519 residues) expressed in bacterial expression system by KdELECT assay
Assay data:2 Active, 2 Tested
KinomeScan assay: inhibition of RIOK3
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human RIOK3 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human RIOK3 assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human RIOK3 assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Binding affinity to RIOK3 (unknown origin)
Assay data:16 Active, 12 Activity ≤ 1 µM, 17 Tested
Inhibition of wild-type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by kinomescan assay relative to control
Inhibition of biotinylated ligand binding to wild-type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system assessed at 50 nM measured after 1 hr by kinomescan assay relative to control
Binding affinity to wild-type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control
Inhibition of wild-type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system at 1 uM by Kinomescan method relative to control
Inhibition of wild-type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system at 10 uM by Kinomescan method relative to control
Binding affinity to wild-type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control
Inhibition of wild-type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system assessed as residual activity at 10 uM by Kinomescan method relative to control
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