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Binding affinity to PPM1B (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate by absorbance based analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PPM1B (unknown origin)
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Time-dependent irreversible inhibition of N-terminal His-tagged PPM1B (unknown origin) expressed in Escherichia coli BL21 (DE3) cells at 80 uM preincubated with enzyme followed by p-nitrophenyl phosphate substrate addition
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Time-dependent irreversible inhibition of N-terminal His-tagged PPM1A (unknown origin) expressed in Escherichia coli BL21 (DE3) cells at 80 uM preincubated with enzyme followed by p-nitrophenyl phosphate substrate addition
Inhibition of human recombinant PPM1A expressed in Escherichia coli up to 100 uM pre-incubated for 10 mins followed by OMFP substrate addition and further incubated for 30 mins by fluorescence based assay
Assay data:3 Tested
SummaryRelated BioAssays by Target
Inhibition of His-tagged PPM1A (unknown origin) at 2 to 10 uM using Ac-TDDE(Nle)T(P)GY(P)VAT-NH2 substrate
Assay data:1 Tested
Inhibition of PPM1A (unknown origin) assessed as reduction in pNPP hydrolysis
Inhibition of wild-type PPM1A expressed in BL21(DE3)pLysS cells at 40 uM after 10 mins by BIOMOL GREEN assay
Late stage assay provider counterscreen for the probe development effort to identify inhibitors of PP5: fluorescence-based biochemical dose response assay to determine activity of inhibitors on dephosphorylation of OMFP by PP2C-alpha (Round 5)
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of PP2Calpha at 100 uM
Inhibition of PP2Calpha at 10 uM
Activation of mouse recombinant GST-tagged PP2Calpha assessed as phosphate release using octapeptide-phosphate substrate RRRRPp-TPA
Assay data:1 Active, 3 Tested
Activation of mouse recombinant GST-tagged PP2Calpha assessed as phosphate release using para-Nitrophenyl phosphate substrate
Inhibition of PP2C alpha
Inhibition of PP2C alpha at 100 uM
Ratio of inhibition of PP1 to that of inhibition of PP2A using pNPP assay
Assay data:2 Tested
Compound was evaluated for inhibitory effect against protein phosphatase I (PP-I)
Assay data:1 Active, 2 Tested
Inhibitory concentration against protein phosphatase 1 (PP1) was determined
Assay data:3 Active, 17 Tested
Inhibitory activity against recombinant Protein phosphatase 1
Assay data:5 Active, 8 Tested
Ratio of IC50 of Protein phosphatase 1 to that of IC50 of Protein phosphatase 2A
Assay data:8 Tested
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