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ML1 CEREP ligand profiling
Assay data:1 Tested
SummaryRelated BioAssays by Target
ML1 Ligand binding assay
Inhibition of human TRPML1deltaNC-YFP expressed in HEK293 cells stimulated with ML-SA1 for 200 secs followed by incubation for 200 secs with compound and measured by Fura-2AM dye based single cell Calcium imaging assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human TRPML1deltaNC-YFP expressed in HEK293 cells at 10 uM stimulated with MK6-83 for 200 secs followed by incubation for 200 secs with compound and measured by Fura-2AM dye based single cell Calcium imaging assay
Activation of human TRPML1deltaNC-YFP expressed in HEK293 cells incubated for 10 mins by Fluo-4 dye calcium imaging based FLIPR analysis
Assay data:1 Active, 15 Tested
Inhibition of human TRPML1deltaNC-YFP expressed in HEK293 cells preincubated for 10 mins followed by stimulation with ML-SA1 and measured after 10 mins by Fluo-4 dye calcium imaging based FLIPR analysis
Assay data:10 Active, 15 Tested
Activation of human TRPML1deltaNC-YFP expressed in HEK293 cells at 10 uM incubated for 200 secs with compound and measured by Fura-2AM dye based single cell Calcium imaging assay
Assay data:1 Active, 1 Tested
Inhibition of human TRPML1deltaNC-YFP expressed in HEK293 cells at 10 uM stimulated with ML-SA1 for 200 secs followed by incubation for 200 secs with compound and measured by Fura-2AM dye based single cell Calcium imaging assay
Assay data:15 Active, 15 Tested
Human TRPML1 (Transient Receptor Potential channels)
Assay data:2 Active, 2 Tested
qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1): Summary
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS for Inhibitors of the Human Mucolipin Transient Receptor Potential 1 (TRPML1): Summary
qHTS for Inhibitors of the Human Mucolipin Transient Receptor Potential 1 (TRPML1)
Assay data:60 Active, 390370 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1)
Assay data:485 Active, 405424 Tested
Late stage counterscreen results from the probe development effort to identify selective agonists of the Transient Receptor Potential Channels 3 (TRPML3): other ion channel Fura-2 profiling assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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