Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of KLK8 (unknown origin) assessed as inhibition of release of AMC fluorescent product using H-VPR-AMC as substrate at 10 uM incubated for 30 mins by microplate reader relative to control
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human C-terminal 10-His-tagged KLK8 (Gln29 to Gly260 residues) expressed in mouse NS0 cells using BOC-VPR-AMC as substrate incubated for 40 mins by FLINT assay
Assay data:13 Active, 9 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant C-terminal 10-His tagged human KLK8 (Gln29 to Gly260 residues) expressed in mouse NS0 cells using BOC-VPR-AMC as substrate after 40 mins by fluorescence intensity assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of KLK8 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured after 30 mins by fluorescence based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Irreversible inhibition of human recombinant KLK8 expressed in Escherichia coli using Boc-Val-Pro-Arg-AMC as fluorogenic substrate at 100 times IC50 preincubated for 15 mins followed by 100 fold dilution measured for 1 hr
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Reversible inhibition of human recombinant KLK8 expressed in Escherichia coli using Boc-Val-Pro-Arg-AMC as fluorogenic substrate at 100 times IC50 preincubated for 15 mins followed by 100 fold dilution measured for 1 hr
Assay data:3 Active, 3 Tested
Inhibition of human recombinant KLK8 expressed in Escherichia coli using Bachem I-1120 as substrate preincubated for 15 mins followed by substrate addition by microplate reader analysis
Assay data:7 Active, 4 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human KLK8 using Boc-Val-Pro-Arg-AMC as substrate at 50 uM after 15 mins by fluorescence assay
Assay data:2 Tested
Inhibition of Kallikrein-8 (unknown origin) using VPR-AMC substrate assessed as residual activity at 10 uM incubated for 15 mins prior to substrate addition measured for 2 hrs
Assay data:1 Tested
Inhibition of Kallikrein-8 (unknown origin) using VPR-AMC substrate incubated for 15 mins prior to substrate addition measured for 2 hrs
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of kallikrein 8 after 10 to 15 mins by fluorescence assay
Inhibition of kallikrein 8 assessed as residual activity at 10 uM after 10 to 15 mins by fluorescence assay relative to control
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on