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Antagonist activity at human RARG in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:5 Active, 36 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human RARG in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:1 Active, 38 Tested
Antagonist activity at human RARA in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:36 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human RARA in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Agonist activity at human RAR-alpha assessed as receptor transactivation at 500 to 20000 nM incubated for 24 hrs by luciferase reporter gene assay
Assay data:1 Tested
Agonist activity at human RAR-alpha assessed as receptor transactivation incubated for 24 hrs by luciferase reporter gene assay
Inhibition of human GAL4-fused RORalpha LBD transfected in HEK293T cell measured after 24 hrs by luciferase reporter assay
Assay data:1 Active, 1 Tested
Activation of RARalpha (unknown origin) at 10 uM
Inverse agonist activity at human GAL4-fused RORalpha LBD transfected in 293T cell measured after 24 hrs by dual luciferase assay
Assay data:6 Tested
Inverse agonist activity at human GAL4-fused RORbeta LBD transfected in 293T cell measured after 24 hrs by dual luciferase assay
Antagonist activity at Gal4-RARalpha transfected in HEK293 cells assessed as atRA-induced RARalpha transactivation and measured after 6 hrs by Dual-Light chemiluminiscence assay
Inhibition of human GAL4-fused RORbeta LBD transfected in HEK293T cell measured for 16 to 20 hrs by by dual-glo luciferase assay
Inhibition of human GAL4-fused RORalpha LBD transfected in HEK293T cell measured for 16 to 20 hrs by by dual-glo luciferase assay
Inverse agonist activity at 6His-tagged RORB LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of biotinylated SRC1-2 derived CPSSHSSLTERHKILHRLLQEGSPS-NH2 containing LXXLL coactivator peptide incubated for 3 hrs by TR-FRET assay
Inverse agonist activity at 6His-tagged RORA LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of biotinylated SRC1-2 derived CPSSHSSLTERHKILHRLLQEGSPS-NH2 containing LXXLL coactivator peptide incubated for 3 hrs by TR-FRET assay
Inhibition of RORbeta (unknown origin) assessed as fold change
Inhibition of RORalpha (unknown origin) assessed as fold change
Agonist activity at human RAR-alpha expressed in CHO-K1 cells by PathHunter assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human RAR-alpha expressed in CHO-K1 cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to 9-cis-retinoic acid
Inhibition of GAL4 DNA-binding domain fused full length human RORbeta (201 to 459 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by one hybrid reporter assay
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