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Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
cAMP Assay from US Patent US10370368: "Aryl acylsulfonamides as BLT1 antagonists"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
BLT-1 cAMP Assay from US Patent US10336733: "Aryl acylsulfonamides as BLT1 antagonists"
Assay data:46 Active, 40 Activity ≤ 1 µM, 46 Tested
PRESTO-Tango GPCRome screening (LTB4R)
Assay data:1 Tested
SummaryRelated BioAssays by Target
LTB4 (h) (BLT1) CEREP ligand profiling
Binding assay (LTB4R )
BLT1/H Cerep selectivity data (BI)
Agonist activity at human BLT1 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
Assay data:13 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of LTB4 (unknown origin) at 0.1 to 1 uM
Agonist activity at human BLT1 isoform 1 expressed in CHO-K1 cells over-expressing GNA15/16 assessed as stimulation of IP-1 accumulation at >=20 uM incubated for 90 mins by IP-one assay relative to control
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human BLT1 isoform 1 expressed in CHO-K1 cells over-expressing GNA15/16 assessed as stimulation of IP-1 accumulation at >=10 uM incubated for 90 mins by IP-one assay relative to control
Assay data:3 Active, 3 Tested
Agonist activity at human BLT1 isoform 1 expressed in CHO-K1 cells over-expressing GNA15/16 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay relative to control
Assay data:47 Tested
Inhibition of human BLT expressed in CHO-K1 cells at 10 uM relative to control
Inhibition of LTB4 (unknown origin) by EIA
Activity at human LTB4 receptor up to 10 uM
Activity at human BLT1 receptor at 10 uM
Displacement of [3H]LTB4 to recombinant human LTB4 receptor at 10 uM after 60 mins by scintillation counting analysis relative to control
Mouse BLT1 receptor (Leukotriene receptors)
Rat BLT1 receptor (Leukotriene receptors)
Human BLT1 receptor (Leukotriene receptors)
Assay data:14 Active, 14 Tested
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