Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of sigma 2 receptor (unknown origin)
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes assessed as inhibition constant presence of haloperidol by scintillation counting analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes assessed as inhibition constant presence of dextrallorphan
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of haloperidol measured for 120 mins by scintillation counting analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of (+)-SKF10047 by radioligand binding assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by radioligand binding assay
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as displacement of compound by measuring inhibition constant of 2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-5-methoxy-3,4-dihydroisoquinolin-1(2H)-one incubated for 120 mins by saturation binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as displacement of compound by measuring inhibition constant of DTG incubated for 120 mins by saturation binding assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as increase in fluorescent intensity pretreated with (+)-pentazocine for 60 mins followed by compound addition incubated for 45 mins by flow cytometric analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]DTG from sigma 2 receptor in Wistar Han rat liver membrane assessed as inhibition constant incubated for 120 mins
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Displacement of [3H]RHM-1 from sigma 2 receptor in Wistar Han rat liver membrane assessed as inhibition constant by competitive binding assay
Displacement of [3H]DTG from sigma 2 receptor in Wistar Han rat liver membrane assessed as inhibition constant by competitive binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to sigma 2 receptor (unknown origin) assessed as inhibition constant
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]DTG from sigma-2 receptor in HEK293 cell membrane assessed as inhibition constant
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
Inhibition of Sigma2 receptor (unknown origin) at 10 uM
Displacement of [3H]DTG from sigma 2 receptor expressed in rat liver membranes assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by radioligand binding assay
Displacement of [3H]DTG from sigma 2 receptor expressed in rat liver membranes assessed as inhibition constant in presence of (+)-pentazocine by radioligand binding assay
Assay data:10 Active, 9 Activity ≤ 1 µM, 10 Tested
Binding affinity to sigma 2 receptor (unknown origin) expressed in human RT-4 cells
Binding affinity to sigma 2 receptor expressed in rat liver
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on