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Agonist activity at NPRB in human HeLa cells assessed as increased cGMP formation at 1 uM incubated for 30 mins in presence of IBMX by ELISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at NPRA in human HeLa cells assessed as increased cGMP formation at 1 uM incubated for 30 mins in presence of IBMX by ELISA
Agonist activity at NPRC in human Hela cells assessed as decrease in forskolin-induced cAMP level at 100 uM in presence of osteocrin
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at NPRC in human Hela cells assessed as decrease in forskolin-induced cAMP level at 100 uM in presence of M372049
Agonist activity at NPRC in human Hela cells assessed as decrease in forskolin-induced cAMP level at 100 uM relative to control
Binding affinity to CM5 sensor chip immobilized human NPR-C (27 to 541 residues) assessed as maximum response by surface plasmon resonance analysis relative to control
Binding affinity to CM5 sensor chip immobilized human NPR-C (27 to 541 residues) assessed as dissociation constant by surface plasmon resonance analysis
Assay data:22 Tested
Agonist activity at NPRB in human HeLa cells assessed as increased cGMP formation at 10 uM incubated for 30 mins in presence of IBMX by ELISA
Assay data:10 Tested
Agonist activity at NPRA in human HeLa cells assessed as increased cGMP formation at 10 uM incubated for 30 mins in presence of IBMX by ELISA
Agonist activity at NPRC in human HeLa cells assessed as decrease in forskolin-induced cAMP level at 100 nM in presence of M372049
Assay data:1 Tested
Agonist activity at NPRC in human HeLa cells assessed as decrease in forskolin-induced cAMP level at 100 nM in presence of osteocrin
Agonist activity at NPRC in human HeLa cells assessed as decrease in forskolin-induced cAMP level at 100 nM
Agonist activity at NPRC in knock out mouse mesenteric arteries assessed as vasorelaxation by Organ bath assay
Assay data:2 Active, 3 Tested
Agonist activity at NPRC in wild type mouse mesenteric arteries assessed as vasorelaxation by Organ bath assay
Assay data:3 Active, 3 Tested
Displacement of Flu-P19 probe from human NPR-C (27 to 541 residues) at 300 uM by fluorescence polarization analysis relative to control
Displacement of Flu-P19 probe from human NPR-C (27 to 541 residues) by fluorescence polarization analysis
Assay data:5 Tested
Vasoreactivity in Rat Mesenteric Arteries In Vitro from US Patent US10087144: "Agents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 H)-quinolone"
Assay data:4 Active, 1 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Atrial Natriuretic Factor (ANF) Eurofins-Panlabs radioligand binding assay
SummaryRelated BioAssays by Target
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-3-isobutylxanthine by radioimmunoassay
Assay data:14 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubated for 2 hrs by top count method
Assay data:26 Active, 16 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
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