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BINDING INHIBITION ACTIVITY EVALUATION TEST from US Patent US20240150287: "N-(BENZOYL)-PHENYLALANINE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF"
Assay data:36 Active, 2 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of alpha2beta1 integrin-mediated cell adhesion to type 1 collagen in human platelets incubated for 30 mins in presence of ADP by microplate reader analysis
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to integrin alpha5beta1 (unknown origin) assessed as inhibition of integrin and fibronectin interaction
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Solid Phase Integrin αvβ1 Binding Assay from US Patent US20230365556: "N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE"
Assay data:20 Active, 23 Activity ≤ 1 µM, 23 Tested
Cell Adhesion Assay from US Patent US11530180: "Alpha-5 beta-1 inhibitors"
Assay data:29 Active, 25 Activity ≤ 1 µM, 30 Tested
Inhibition of human recombinant integrin alpha5beta1 incubated for 1 hr by ELISA assay
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of alpha5beta1 integrin receptor expressed on human surface of adipose tissue-derived stem cells
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Cell adhesion assay to Hamster Ovary from US Patent US10836720: "Inhibitors of integrin alpha 5 beta 1 and methods of use"
Assay data:10 Active, 5 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Cell adhesion assay to SW480 from US Patent US10836720: "Inhibitors of integrin alpha 5 beta 1 and methods of use"
Assay data:7 Active, 4 Activity ≤ 1 µM, 11 Tested
Solid Phase Receptor Assay (SPRA) for alpha5beta1 Function from US Patent US10577330: "Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists"
Assay data:28 Active, 16 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
Binding Inhibition Assay from US Patent US9533985: "Sulfonamide derivative and medicinal use thereof"
Assay data:103 Active, 1 Activity ≤ 1 nM, 104 Activity ≤ 1 µM, 104 Tested
Assay data:40 Active, 30 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 40 Tested
Assay data:40 Active, 37 Activity ≤ 1 µM, 40 Tested
Competitive Cell Adhesion Assay from Article 10.1021/jm070790o: "Highly Potent, Water Soluble Benzimidazole Antagonist for Activated alpha(4)beta(1) Integrin."
Assay data:10 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Specificity of Inhibitors on Cell Adhesion Assay from Article 10.1021/jm070252b: "Small molecule inhibitors of integrin alpha2beta1."
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Human Platelet Adhesion Assay from Article 10.1021/jm070252b: "Small molecule inhibitors of integrin alpha2beta1."
Assay data:25 Active, 25 Activity ≤ 1 µM, 28 Tested
VLA-4/VCAM-1 binding assay from Article 10.1016/j.bmc.2005.11.058: "Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists."
Assay data:24 Active, 4 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested
VLA-4/VCAM-1 binding assay from Article 10.1016/j.bmc.2006.12.006: "Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists."
Assay data:18 Active, 3 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
K562 Cell Adhesion Assay (alpha4beta7 Mediated Adhesion/MAdCAM-1) from Article 10.1016/j.bmc.2006.01.067: "Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Ramos Cell Adhesion Assay (alpha4beta1 Mediated Adhesion/VCAM-1) from Article 10.1016/j.bmc.2006.01.067: "Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent."
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