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Inhibition of human TS
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of DHFR (unknown origin) incubated for 2 to 5 mins by absorbance based analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of DHFR (unknown origin)
Inhibition of human DHFR using TMB as substrate incubated for 1.5 hrs by ELISA assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Escherichia coli DHFR assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of Escherichia coli DfrA1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Escherichia coli DHFR
Assay data:3 Active, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of Escherichia coli DHFR in presence of NADPH
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human DHFR
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Assay data:11 Tested
TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Assay data:50 Active, 50 Activity ≤ 1 µM, 50 Tested
Assay data:58 Active, 25 Activity ≤ 1 µM, 63 Tested
Inhibition of Thymidylate synthase (unknown origin)
Inhibition of DHFR (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Escherichia coli N-terminal hexahstidine-tagged TS at 500 uM by steady-state kinetic analysis
Assay data:3 Tested
Binding affinity to Escherichia coli N-terminal hexahistidine tagged TS assessed as change in entropy at 0.2 mM by isothermal titration calorimetry method
Binding affinity to Escherichia coli N-terminal hexahistidine tagged TS assessed as change in gibbs free energy at 0.2 mM by isothermal titration calorimetry method
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