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ELISA Assay to Measure Human Heme Oxygenase-1 (HMOX-1) in HepG2 lysate from US Patent US20240051952: "HMOX1 INDUCERS"
Assay data:126 Active, 26 Activity ≤ 1 µM, 126 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human HO-1 activity in human U-87MG cells assessed as reduction in immunoreactivity in cytoplasm at 10 uM incubated for 48 hrs by DAPI staining analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human HO-1 activity in human U-87MG cells assessed as bilirubin formation at 10 uM incubated for 24 hrs
Inhibition of Sprague-Dawley rat spleen microsome HO-1 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry
Assay data:11 Active, 5 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Sprague-Dawley rat brain microsome HO-2 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry
Assay data:4 Active, 2 Activity ≤ 1 µM, 24 Tested
Heme Oxygenase from Article 10.1111/j.1747-0285.2009.00909.x: "Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone."
Assay data:4 Active, 1 Activity ≤ 1 µM, 57 Tested
In Vitro HO Activity Assay from Article 10.1124/jpet.106.102699: "Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs."
Assay data:5 Active, 2 Activity ≤ 1 µM, 9 Tested
In Vitro HO Activity Assay from Article 10.1016/j.bmc.2009.01.078: "Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring."
Assay data:30 Active, 8 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Covalent binding affinity to HMOX2 at Cys282 residue in human NCI-H358 cells assessed as reduction of log2 H/L ratio for tryptic peptide GALEGSSCPFR incubated for 4 hrs followed by cell lysis and subsequently labelled with light thiol probe N-((S)-18-iodo-11-isopropyl-10,13,17-trioxo-3,6-dioxa-9,12,16-triazaoctadecyl)-6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanamide and heavy thiol probe 4 for 1 hr under dark conditions followed by tryptic digestion for overnight and measured by discovery ABPP based nano LC-MS/MS analysis
Covalent binding affinity to HMOX2 at Cys282 residue in human NCI-H358 cells assessed as log2 H/L ratio at 10 uM pretreated for 3 hrs followed by N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-hydroxyacetamide treatment for 3 hrs by competitive TMT click chemistry pull-down experiment based LC-MS/MS analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to HMOX2 in human HePAD38 cells infected with HBV assessed as protein labelling at 20 uM after 1 hr by photoaffinity labelling in-situ fluorescence gel-based LC-MS/MS analysis
Inhibition of human recombinant HO-1 by spectrometry based assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of HO-2 in Sprague-Dawley rat brain microsomes using NADPH as substrate incubated for 60 mins by spectrometry based assay
Inhibition of HO-1 in rat spleen microsomes incubated for 15 mins
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of HO-1 in Sprague-Dawley rat spleen microsomes using NADPH as substrate incubated for 60 mins by spectrometry based assay
Assay data:5 Active, 9 Tested
Inhibition of HO-2 in Sprague-Dawley rat brain microsomes using NADPH as substrate preincubated for 10 mins followed by substrate addition and measured after 15 mins by GC analysis
Assay data:6 Active, 9 Tested
Inhibition of HO-1 in Sprague-Dawley rat spleen microsomes using NADPH as substrate preincubated for 10 mins followed by substrate addition and measured after 15 mins by GC analysis
Assay data:2 Active, 9 Tested
Inhibition of recombinant truncated HO-2 (Met1 to Ala288) in rat brain microsomes expressed in Escherichia coli by spectrometry based assay
Inhibition of recombinant truncated HO-1 (Met1 to Pro267) in rat spleen microsomes expressed in Escherichia coli by spectrometry based assay
Inhibition of HO-2 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
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