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Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Irreversible inhibition of MPO (unknown origin) assessed as fold shift in EC50 incubated with compound followed by drug washing and later treated with H2O2 for enzyme reactivation by chemiluminescence assay
Assay data:17 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assay
Assay data:8 Active, 1 Activity ≤ 1 µM, 17 Tested
Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assay
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
MPO Chlorination Assay (APF Assay) from US Patent US11059818: "Triazolopyridine inhibitors of myeloperoxidase"
Assay data:55 Active, 53 Activity ≤ 1 µM, 55 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
MPO Peroxidation Assay (Amplex Red Assay) from US Patent US11059818: "Triazolopyridine inhibitors of myeloperoxidase"
Assay data:56 Active, 40 Activity ≤ 1 µM, 56 Tested
Pharmacological Activity Assay from US Patent US11000525: "1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase"
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
MPO Peroxidation (Amplex Red) Assay from US Patent US10981879: "Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase"
Assay data:24 Active, 24 Activity ≤ 1 µM, 24 Tested
MPO Chlorination (APF) Assay from US Patent US10981879: "Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase"
Assay data:164 Active, 164 Activity ≤ 1 µM, 164 Tested
MPO Chlorination Assay (APF Assay) from US Patent US10577383: "Macrocyclic inhibitors of myeloperoxidase"
Assay data:37 Active, 36 Activity ≤ 1 µM, 37 Tested
MPO Peroxidation Assay (Amplex Red Assay) from US Patent US10577383: "Macrocyclic inhibitors of myeloperoxidase"
Assay data:37 Active, 27 Activity ≤ 1 µM, 37 Tested
EPX Bromination Assay from US Patent US10577383: "Macrocyclic inhibitors of myeloperoxidase"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
EPX Bromination Assay from US Patent US10407422: "Triazolopyridine inhibitors of myeloperoxidase"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Surface Plasmon Resonance (SPR) from Article 10.1074/jbc.M113.507756: "Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates."
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Myeloperoxidase Assay from Article 10.1074/jbc.M113.507756: "Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates."
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
MPO Activity Assay from Article 10.1021/bi401354d: "Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling."
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Activity Assay from Article 10.1074/jbc.M111.266981: "2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation."
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Pharmacological Activity Assay from US Patent US10016430: "1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase"
MPO Peroxidation Assay (Amplex Red Assay) from US Patent US10214527: "Triazolopyridine inhibitors of myeloperoxidase"
Assay data:65 Active, 62 Activity ≤ 1 µM, 65 Tested
MPO Chlorination Assay (APF Assay) from US Patent US10214527: "Triazolopyridine inhibitors of myeloperoxidase"
Assay data:25 Active, 24 Activity ≤ 1 µM, 25 Tested
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