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Binding affinity to CypB (unknown origin)
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CypD (unknown origin)
Assay data:2 Active, 2 Tested
Inhibition of CypC (unknown origin)
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CypB (unknown origin)
Inhibition of CypA (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to CypD (unknown origin)
Assay data:3 Active, 3 Tested
Binding affinity to CypA (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
Surface Plasmon Resonance (SPR) Assay from US Patent US11802108: "Compounds for the modulation of cyclophilins function"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Isothermal Titration Calorimetry (ITC) from US Patent US11802108: "Compounds for the modulation of cyclophilins function"
Assay data:8 Active, 4 Activity ≤ 1 µM, 21 Tested
Inhibition of CypA (unknown origin) upto 20 uM
Binding affinity to CypA (unknown origin) assessed as inhibition constant by isomer specific proteolysis assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
Binding affinity to His6-tagged CypA (unknown origin) expressed in Escherichia coli BL21 (DE3) incubation at 1 hr by multimode plate reader
Assay data:6 Active, 11 Tested
Inhibition Assay from US Patent US9090657: "Compound and methods for its production"
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Enzymatic Assay from US Patent US8901295: "Inhibitors of cyclophilins and uses thereof"
Assay data:11 Active, 3 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Surface Plasmon Resonance Assay from Article 10.1021/cc0501561: "Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay."
Assay data:10 Active, 5 Activity ≤ 1 µM, 16 Tested
PPIase Assay from Article 10.1021/bi9007287: "Isoform-specific inhibition of cyclophilins."
Assay data:4 Active, 2 Activity ≤ 1 µM, 9 Tested
PPIase Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:1 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
ESI-MS Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:6 Tested
Enzymatic Assay from US Patent US9975902: "Compounds for the inhibition of cyclophilins and uses thereof"
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
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