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Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000153b PDPK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (ELISA (phosphorylation of Thr308-AKT (PI3K-dependent) in PC-3 cells)) EUB0000153b PDPK1
Inhibition of PDK1 (unknown origin)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PDPK1 DiscoveRx kinase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Mobility Shift Assay from US Patent US9365572: "PI3K and/or mTOR inhibitor"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Silico Screening Assay from US Patent US9320734: "Small molecule inhibitors of the pleckstrin homology domain and methods for using same"
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
Luminex Assay from US Patent US9238651: "1-H-pyrrolo[2,3-b]pyridine derivatives"
Assay data:29 Active, 24 Activity ≤ 1 µM, 36 Tested
PDK1 Enzymatic Assay from US Patent US9238651: "1-H-pyrrolo[2,3-b]pyridine derivatives"
Assay data:36 Active, 35 Activity ≤ 1 µM, 36 Tested
Isothermal titration calorimetry from Article 10.1016/j.chembiol.2016.06.017: "Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase."
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Kinase Assay from US Patent US8895581: "1H-imidazo[4,5-c]quinolines"
Assay data:94 Active, 9 Activity ≤ 1 nM, 91 Activity ≤ 1 µM, 94 Tested
In Vitro Kinase Assay from US Patent US8741944: "Anti-infective agents against intracellular pathogens"
Assay data:4 Active, 37 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition Assay from US Patent US8664236: "1H-pyrrolo[2,3 b]-pyridine derivatives"
Assay data:35 Active, 34 Activity ≤ 1 µM, 35 Tested
Enzyme Assay from US Patent US8637532: "Amino azaheterocyclic carboxamides"
Assay data:22 Active, 17 Activity ≤ 1 µM, 37 Tested
Fluorescence Polarization Assay from US Patent US8628961: "Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof"
Assay data:7 Tested
EGFR, MAPK and PDK Inhibitory Acitivity Assay from Article 10.1016/j.bioorg.2014.02.001: "Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives."
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Kinase Assay from US Patent US8575203: "Chemical compounds"
Assay data:253 Active, 3 Activity ≤ 1 nM, 252 Activity ≤ 1 µM, 253 Tested
AlphaScreen Assay from Article 10.1021/cb400452z: "PIF-pocket as a target for C. albicans Pkh selective inhibitors."
Assay data:5 Tested
Protein Kinase Activity Assay from Article 10.1021/cb400452z: "PIF-pocket as a target for C. albicans Pkh selective inhibitors."
Binding Assay from US Patent US8569511: "Substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs as inhibitors of the PDK1 kinase"
Assay data:12 Active, 8 Activity ≤ 1 µM, 19 Tested
Activity Assay from US Patent US8569511: "Substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs as inhibitors of the PDK1 kinase"
Assay data:10 Active, 5 Activity ≤ 1 µM, 21 Tested
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