Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of Fatty acid synthase in chicken liver using [3H]-acetyl CoA as substrate preincubated for 30 mins followed by substrate addition and measured after 10 mins in presence of NADPH by scintillation counting analysis
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Affinity Biochemical interaction (Human FAS enzyme assay (measuring consumption of NADPH)) EUB0000738a FASN
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity Biochemical interaction (Human FAS enzyme assay (measuring consumption of NADPH)) EUB0000294b FASN
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity On-target Cellular interaction (Cellular activity assay (inhibition of [14C]acetate incorporation into human H1975 cells)) EUB0000294b FASN
Inhibition of human FASN enoyl reductase activity using crotonyl CoA as substrate assessed as inhibition of substrate hydrolysis measured every 1 min for 10 mins in the presence of NADPH by fluorescence based assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of FASN in human MDA-MB-231 cells overexpressing FASN assessed as decrease in endogenous FFA level at IC50 concentration incubated for 72 hrs
Assay data:2 Active, 2 Tested
Inhibition Scintillation Proximity Assay from US Patent US10413545: "Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer"
Assay data:97 Active, 81 Activity ≤ 1 µM, 97 Tested
Biochemical Assay from US Patent US9428502: "Heterocyclic modulators of lipid synthesis"
Assay data:328 Active, 309 Activity ≤ 1 µM, 335 Tested
FAS Inhibitory Assay from Article 10.3109/14756366.2012.658786: "Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity."
Assay data:1 Active, 5 Tested
FAS Activity Assay from Article 10.3109/14756360903179377: "Inhibitory effects of thioethers on fatty acid synthase and 3T3-L1 cells."
Assay data:1 Active, 3 Tested
Biochemical Assay from US Patent US8871790: "Heterocyclic modulators of lipid synthesis"
Assay data:419 Active, 358 Activity ≤ 1 µM, 472 Tested
Biological Assay from US Patent US8802864: "Triazolones as fatty acid synthase inhibitors"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
FAS Assay No2 from Article 10.1038/nchembio.1603: "A human fatty acid synthase inhibitor binds -ketoacyl reductase in the keto-substrate site."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
FAS Assay No1 from Article 10.1038/nchembio.1603: "A human fatty acid synthase inhibitor binds -ketoacyl reductase in the keto-substrate site."
Biochemical Activity Assay from US Patent US9994550: "Heterocyclic modulators of lipid synthesis for use against cancer and viral infections"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Fluorogenic Assay for Detection of FASTE Inhibition from Article 10.1158/1535-7163.MCT-07-0187: "Novel antagonists of the thioesterase domain of human fatty acid synthase."
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorogenic Assay for Detection of FASTE Inhibition from Article 10.1016/j.bmcl.2008.02.043: "Beta-lactam congeners of orlistat as inhibitors of fatty acid synthase."
Assay data:1 Active, 9 Tested
Fluorogenic Assay for Detection of FASTE Inhibition from Article 10.1021/jm800321h: "Synthesis of novel beta-lactone inhibitors of fatty acid synthase."
Assay data:24 Active, 16 Activity ≤ 1 µM, 27 Tested
FASN Inhibition from US Patent US10226449: "Heterocyclic modulators of lipid synthesis and combinations thereof"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fatty Acid Synthase (FASN) Inhibition Scintillation Proximity Assay from US Patent US9718813: "Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer"
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on