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Inhibition of DHFR (unknown origin) incubated for 2 to 5 mins by absorbance based analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of DHFR (unknown origin)
Inhibition of human DHFR using TMB as substrate incubated for 1.5 hrs by ELISA assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Staphylococcus aureus DHFR
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of wild type Staphylococcus aureus DHFR
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of human DHFR
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Assay data:11 Tested
TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:58 Active, 25 Activity ≤ 1 µM, 63 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of DHFR (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of DHFR (unknown origin) at pH 6.7
Inhibition of recombinant human DHFR expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis
Assay data:6 Active, 1 Activity ≤ 1 µM, 34 Tested
Inhibition of recombinant human DHFR expressed in Escherichia coli incubated for 15 mins and measured by ELISA
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
Kinase Inhibition Assay from US Patent US11111252: "Pyrimidine compounds and pyrimido indole compounds and methods of use"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibitory Activity Assay from US Patent US11078214: "Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TBD from US Patent US11001595: "Pyrimidine compounds and pyrimido indole compounds and methods of use"
Assay data:8 Active, 4 Activity ≤ 1 µM, 9 Tested
Enzyme Inhibition from US Patent US10870625: "Zwitterionic propargyl-linked antifolates useful for treating bacterial infections"
Assay data:9 Active, 4 Activity ≤ 1 µM, 10 Tested
Biological Assay from Article 10.3109/14756360903179443: "Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms."
Assay data:13 Active, 11 Activity ≤ 1 µM, 21 Tested
Dihydrofolate Reductase (DHFR) Inhibition Assay from Article 10.1016/j.bioorg.2017.04.019: "Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors"
Assay data:11 Active, 5 Activity ≤ 1 µM, 20 Tested
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