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Erythrocyte KCa3.1 Assay from US Patent US20240034717: "NOVEL POTASSIUM CHANNEL INHIBITORS"
Assay data:82 Active, 82 Activity ≤ 1 µM, 82 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Potentiation of human KCa3.1 expressed in HEK293 cells at 0.01 to 100 uM with -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology relative to calcium
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Electrophysiology Assay from US Patent US9611232: "Oxazolidinone and imidazolidinone compounds"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition Assay from US Patent US9556132: "Tetrazole derivatives and their use as potassium channel modulators"
Assay data:39 Active, 33 Activity ≤ 1 µM, 39 Tested
KCa3.1 Assay from US Patent US9533999: "Fused thiazin-3-ones as KCA3.1 inhibitors"
Assay data:64 Active, 51 Activity ≤ 1 µM, 64 Tested
SK+Ca channel CEREP ligand profiling
Assay data:1 Tested
SummaryRelated BioAssays by Target
SKCa channel CEREP ligand profiling
K+ channel (Ca2+-dependent) CEREP ligand profiling
K+ channel (Ca2+ - dependent) Ligand binding assay
SK+ channel CEREP ligand profiling
Inhibition of Kca3.1 in human erythrocytes
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of Kca3.1 (unknown origin) at 30 uM by manual patch clamp method relative to control
Human KCa3.1 (Calcium- and sodium-activated potassium channels)
Assay data:17 Active, 17 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of IKCa1 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition measured for 50 secs by FLIPR assay
Inhibition of Kca 3.1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of gardos channel (unknown origin)
Inhibition of IK channel (unknown origin)
Assay data:8 Active, 2 Activity ≤ 1 µM, 23 Tested
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